Probucol
Probucol Uses, Dosage, Side Effects, Food Interaction and all others data.
A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).
Probucol lowers cholesterol levels by increasing LDL (low-density lipoprotein) breakdown. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.
| Trade Name | Probucol |
| Availability | Discontinued |
| Generic | Probucol |
| Probucol Other Names | Biphenabid, Bisbid, Bisphenabid, Probucol, Probucolum |
| Related Drugs | Zetia, Praluent, Repatha, atorvastatin, simvastatin, rosuvastatin, Lipitor, ezetimibe, Crestor |
| Type | Oral |
| Formula | C31H48O2S2 |
| Weight | Average: 516.842 Monoisotopic: 516.30957216 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used to lower LDL and HDL cholesterol.
How Probucol works
Probucol lowers serum cholesterol by increasing the fractional rate of low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination from the body. This drug may also act to inhibit the initial stages of cholesterol synthesis and act to inhibit the absorption of cholesterol from the diet. Recent information suggests that probucol may inhibit the oxidation and tissue deposition of LDL cholesterol, thereby inhibiting atherogenesis. It appears to inhibits ABCA1-mediated cellular lipid efflux.
Food Interaction
- Take with food. Food increases bioavailability.
Elimination Route
Absorption from the gastrointestinal tract is limited and variable (about 7%).
Half Life
Ranges from 12 hours to more than 500 hours, the longest half-life probably being in adipose tissue.
Innovators Monograph
You find simplified version here Probucol
