Probucol

Probucol Uses, Dosage, Side Effects, Food Interaction and all others data.

A drug used to lower LDL and HDL cholesterol yet has little effect on serum-triglyceride or VLDL cholesterol. (From Martindale, The Extra Pharmacopoeia, 30th ed, p993).

Probucol lowers cholesterol levels by increasing LDL (low-density lipoprotein) breakdown. Additionally, probucol may inhibit cholesterol synthesis and delay cholesterol absorption. Probucol is a powerful antioxidant drug normally used to prevent vascular disease caused by the free radicals in the body.

Trade Name Probucol
Availability Discontinued
Generic Probucol
Probucol Other Names Biphenabid, Bisbid, Bisphenabid, Probucol, Probucolum
Related Drugs Zetia, Praluent, Repatha, atorvastatin, simvastatin, rosuvastatin, Lipitor, ezetimibe, Crestor
Type Oral
Formula C31H48O2S2
Weight Average: 516.842
Monoisotopic: 516.30957216
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Probucol
Probucol

Uses

Used to lower LDL and HDL cholesterol.

How Probucol works

Probucol lowers serum cholesterol by increasing the fractional rate of low-density lipoprotein (LDL) catabolism in the final metabolic pathway for cholesterol elimination from the body. This drug may also act to inhibit the initial stages of cholesterol synthesis and act to inhibit the absorption of cholesterol from the diet. Recent information suggests that probucol may inhibit the oxidation and tissue deposition of LDL cholesterol, thereby inhibiting atherogenesis. It appears to inhibits ABCA1-mediated cellular lipid efflux.

Food Interaction

  • Take with food. Food increases bioavailability.

Elimination Route

Absorption from the gastrointestinal tract is limited and variable (about 7%).

Half Life

Ranges from 12 hours to more than 500 hours, the longest half-life probably being in adipose tissue.

Innovators Monograph

You find simplified version here Probucol

http://classyfire.wishartlab.com/tax_nodes/C0000000
http://classyfire.wishartlab.com/tax_nodes/C0002448
http://classyfire.wishartlab.com/tax_nodes/C0002279
http://classyfire.wishartlab.com/tax_nodes/C0002811
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http://classyfire.wishartlab.com/tax_nodes/C0002359
http://classyfire.wishartlab.com/tax_nodes/C0000134
http://classyfire.wishartlab.com/tax_nodes/C0002133
http://classyfire.wishartlab.com/tax_nodes/C0003863
http://classyfire.wishartlab.com/tax_nodes/C0003260
http://classyfire.wishartlab.com/tax_nodes/C0000323
http://classyfire.wishartlab.com/tax_nodes/C0004150
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:8427
http://www.hmdb.ca/metabolites/HMDB0015537
http://www.genome.jp/dbget-bin/www_bget?drug:D00476
http://www.genome.jp/dbget-bin/www_bget?cpd:C07373
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=4912
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46508876
https://www.chemspider.com/Chemical-Structure.4743.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50007260
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=8699
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=8427
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL608
https://zinc.docking.org/substances/ZINC000001530755
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP000916
http://www.pharmgkb.org/drug/PA451107
https://www.drugs.com/cons/probucol.html
https://en.wikipedia.org/wiki/Probucol
*** Taking medicines without doctor's advice can cause long-term problems.
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