Quarzan
Quarzan Uses, Dosage, Side Effects, Food Interaction and all others data.
Quarzan is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract. It inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites. It is used for the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Quarzan is a synthetic anticholinergic agent which has been shown in experimental and clinical studies to have a pronounced antispasmodic and antisecretory effect on the gastrointestinal tract.
| Trade Name | Quarzan |
| Availability | Prescription only |
| Generic | Clidinium |
| Clidinium Other Names | Bromure de Clidinium, Bromuro de clidinio, Clidinii Bromidum, Clidinium bromid |
| Related Drugs | famotidine, pantoprazole, Pepcid, Protonix, glycopyrrolate, Librax |
| Type | |
| Formula | C22H26NO3 |
| Weight | Average: 352.4467 Monoisotopic: 352.191268703 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Quarzan is a synthetic anticholinergic used to treat peptic ulcer disease, colicky abdominal pain, diverticulitis, and IBS.
For the treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.
Quarzan is also used to associated treatment for these conditions: Irritable Bowel Syndrome (IBS), Peptic Ulcer Disease, Acute Enterocolitis
How Quarzan works
Inhibits muscarinic actions of acetylcholine at postganglionic parasympathetic neuroeffector sites primarily by inhibiting the M1 muscarinic receptors.
Toxicity
Signs of toxicity include confusion, paralytic ileus, urinary hesitancy/retention, and blurred vision.
Food Interaction
- Avoid alcohol. Ingesting alcohol may increase the CNS depressant effects of the combination product Chlordiazepoxide HCl and Quarzan Bromide.
- Take before a meal.
Quarzan Alcohol interaction
[Moderate] GENERALLY AVOID:
Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous.
In addition, the potential for abuse may be increased with the combination.
The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system.
No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load.
However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
Alcohol should generally be avoided during therapy with anticholinergic agents.
Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
Quarzan Hypertension interaction
[Minor] Cardiovascular effects of anticholinergics may exacerbate hypertension.
Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
Quarzan Drug Interaction
Moderate: hydroxyzine, hydroxyzine, metoprolol, metoprololMinor: acetaminophen, acetaminophenUnknown: aspirin, aspirin, ibuprofen, ibuprofen, multivitamin, multivitamin, dexlansoprazole, dexlansoprazole, montelukast, montelukast, cyanocobalamin, cyanocobalamin, cholecalciferol, cholecalciferol
Quarzan Disease Interaction
Major: arrhythmias, autonomic neuropathy, GI obstruction, glaucoma, obstructive uropathy, tardive dyskinesia, infectious diarrheaModerate: psychosesMinor: hypertension, fever
Innovators Monograph
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