Recombinant Human Mannose-binding Lectin
Recombinant Human Mannose-binding Lectin Uses, Dosage, Side Effects, Food Interaction and all others data.
Recombinant Human Mannose-binding Lectin is a protein therapeutic being developed by Enzon for the prevention and treatment of severe infections in individuals with low levels of Mannose-Binding Lectin (MBL). Over 10 percent of the general population is estimated to be MBL-deficient. Natural MBL is a 400-700kDa oligomer made of 3 identical 32kDa peptide chains.
MBL forms different oligomers but must form at least a tetramer to be active.
Trade Name | Recombinant Human Mannose-binding Lectin |
Generic | rhMBL |
rhMBL Other Names | Recombinant human mannan-binding protein, Recombinant human mannose-binding lectin, rhMBP |
Type | |
Groups | Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Investigated for use/treatment in immunodeficiency and infectious and parasitic disease (unspecified).
How Recombinant Human Mannose-binding Lectin works
MBL deficiency may explain why some but not all individuals who are immunosuppressed develop infectious complications even when they receive prophylactic anti-infectious treatment. Studies have shown a correlation between low MBL levels and susceptibility to serious infections in patients immunosuppressed from chemotherapy, including patients with multiple myeloma undergoing high-dose chemotherapy and hematopoietic stem cell transplantation. Recombinant Human Mannose-binding Lectin acts as natural MBL in the body, reducing susceptibility to serious infections.
Innovators Monograph
You find simplified version here Recombinant Human Mannose-binding Lectin