Recombinant Human Mannose-binding Lectin

Recombinant Human Mannose-binding Lectin Uses, Dosage, Side Effects, Food Interaction and all others data.

Recombinant Human Mannose-binding Lectin is a protein therapeutic being developed by Enzon for the prevention and treatment of severe infections in individuals with low levels of Mannose-Binding Lectin (MBL). Over 10 percent of the general population is estimated to be MBL-deficient. Natural MBL is a 400-700kDa oligomer made of 3 identical 32kDa peptide chains.

MBL forms different oligomers but must form at least a tetramer to be active.

Trade Name Recombinant Human Mannose-binding Lectin
Generic rhMBL
rhMBL Other Names Recombinant human mannan-binding protein, Recombinant human mannose-binding lectin, rhMBP
Type
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Recombinant Human Mannose-binding Lectin
Recombinant Human Mannose-binding Lectin

Uses

Investigated for use/treatment in immunodeficiency and infectious and parasitic disease (unspecified).

How Recombinant Human Mannose-binding Lectin works

MBL deficiency may explain why some but not all individuals who are immunosuppressed develop infectious complications even when they receive prophylactic anti-infectious treatment. Studies have shown a correlation between low MBL levels and susceptibility to serious infections in patients immunosuppressed from chemotherapy, including patients with multiple myeloma undergoing high-dose chemotherapy and hematopoietic stem cell transplantation. Recombinant Human Mannose-binding Lectin acts as natural MBL in the body, reducing susceptibility to serious infections.

Innovators Monograph

You find simplified version here Recombinant Human Mannose-binding Lectin

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