Recombinant Platelet-derived Growth Factor BB
Recombinant Platelet-derived Growth Factor BB Uses, Dosage, Side Effects, Food Interaction and all others data.
Recombinant Platelet-derived Growth Factor BB is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Recombinant Platelet-derived Growth Factor BB has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds.
Used for the topical treatment of skin ulcers, Regranex has a biological activity similar to that of endogenous platelet-derived growth factor, which includes promoting the chemotactic recruitment and proliferation of cells involved in wound repair and enhancing the formation of granulation tissue.
| Trade Name | Recombinant Platelet-derived Growth Factor BB |
| Availability | Prescription only |
| Generic | Becaplermin |
| Becaplermin Other Names | Becaplermin, PDGF-2, PDGF-BB, PDGFB, Platelet-derived growth factor BB, recombinant, Platelet-derived growth factor beta polypeptide, Recombinant platelet-derived growth factor BB, rhPDGF-BB, rPDGF-BB, SH-POLYPEPTIDE-59 |
| Related Drugs | Iodosorb, cadexomer iodine topical |
| Type | |
| Formula | C532H892N162O153S9 |
| Weight | 12294.4 Da |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Recombinant Platelet-derived Growth Factor BB is a recombinant form of human platelet-derived growth factor used to treat ulcers due to diabetic neuropathy in the lower extremities when there is adequate blood supply to the area.
For topical treatment of skin ulcers (from diabetes)
Recombinant Platelet-derived Growth Factor BB is also used to associated treatment for these conditions: Skin Ulcer
How Recombinant Platelet-derived Growth Factor BB works
Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta).
Food Interaction
No interactions found.Elimination Route
very little systemic absorption. 15% of patients experienced complete healing within 8 weeks, while for 25% of patients, it was at 10 weeks.
Innovators Monograph
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