Recombinant Thyrotropin Alfa

Recombinant Thyrotropin Alfa Uses, Dosage, Side Effects, Food Interaction and all others data.

Recombinant Thyrotropin Alfa is a recombinant form of thyroid stimulating hormone used in performing certain tests in patients who have or have had thyroid cancer. It is also used along with a radioactive agent to destroy remaining thyroid tissue in certain patients who have had their thyroid gland removed because of thyroid cancer. It is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 112 residues containing one N-linked glycosylation site. The alpha subunit of thyrotropin alfa, which is the effector region responsible for the stimulation of adenylate cyclase, displays close structural similarity with the alpha subunit of human chorionic gonadotropin (hCG), luteinizing hormone (LH), and follicle-stimulating hormone (FSH). The beta subunit (TSHB) bestows its receptor specificity due to the uniqueness to TSH. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.

Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. Thyrogen is an exogenous source of human TSH that offers an additional diagnostic tool in the follow-up of patients with a history of well-differentiated thyroid cancer.

Recombinant Thyrotropin Alfa
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Recombinant Thyrotropin Alfa
Generic	Thyrotropin alfa
Thyrotropin alfa Other Names	Recombinant Human Thyroid Stimulating Hormone, Recombinant thyrotropin alfa, rhTSH, rTSH, Thyrotropin alfa, Thyrotropin alpha
Type
Formula	C₉₇₅H₁₅₁₃N₂₆₇O₃₀₄S₂₆
Weight	22672.9 Da
Groups	Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Recombinant Thyrotropin Alfa is a recombinant form of thyroid stimulating hormone used in diagnostic testing for thyroid cancer and alongside radioactive agents to destroy thyroid tissue.

For detection of residueal or recurrent thyroid cancer

Recombinant Thyrotropin Alfa is also used to associated treatment for these conditions: Thyroid Cancers, Thyroid tissue remnants, Radioiodine ablation of thyroid tissue

How Recombinant Thyrotropin Alfa works

Thyrotropin Alfa binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging.

Toxicity

No difference in efficacy and toxicity between adult and geriatric patients. No studies in lactating women, pregnant women and pediatrics. Cautionary administration is advised.

Food Interaction

No interactions found.

Elimination Route

Time to peak: Median: 10 hours (range: 3-24 hours) After a single intramuscular injection of 0.9 mg of thyrotropin alfa: Cmax= 116+38mU/L, Tmax=22+8.5 hours. AUC=5088+1728 mU·hr/L.