Retabac 1% Ointment
Retabac 1% Ointment Uses, Dosage, Side Effects, Food Interaction and all others data.
Retabac 1% Ointment is a semisynthetic derivative of the compound pleuromutilin. In vitro activity of Retabac 1% Ointment against isolates of Staphylococcus aureus as well as Streptococcus pyogenes has been demonstrated. Retabac 1% Ointment selectively inhibits bacterial protein synthesis by interacting at a site on the 50S subunit of the bacterial ribosome through an interaction that is different from that of other antibiotics.This binding site involves ribosomal protein L3 and is in the region of the ribosomal P-site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions and prevent the normal formation of active 50S ribosomal subunits. Retabac 1% Ointment demonstrates no in vitro target-specific cross-resistance with other classes of antibiotics.
Retabac 1% Ointment is a semisynthetic pleuromutilin antibiotic. This drug is usually bacteriostatic in action, but may become bactericidal at highed concentrations (when MBC is 1000 times higher than MIC). Retabac 1% Ointment acts by selectively inhibiting the initiation of protein synthesis in bacteria at the level of bacterial 50S ribosome.
| Trade Name | Retabac 1% Ointment |
| Generic | Retapamulin |
| Retapamulin Other Names | Retapamulin, Retapamulina |
| Weight | 1% |
| Type | Ointment |
| Formula | C30H47NO4S |
| Weight | Average: 517.763 Monoisotopic: 517.322579687 |
| Protein binding | Retapamulin is approximately 94% bound to human plasma proteins, and the protein binding is independent of concentration. |
| Groups | Approved |
| Therapeutic Class | Topical Antibiotic preparations |
| Manufacturer | Square Pharmaceuticals Ltd. |
| Available Country | Bangladesh |
| Last Updated: | September 24, 2024 at 5:38 am |
Uses
Retabac 1% Ointment ointment is used for the topical treatment of impetigo due to Staphylococcus aureus (methicillin-susceptible isolates only) or Streptococcus pyogenes in patients aged 9 months or older. It is also used to treat infected small lacerations, abrasions or sutured wounds.
Retabac 1% Ointment is also used to associated treatment for these conditions: Staphylococcal impetigo, Streptococcal impetigo
How Retabac 1% Ointment works
Retabac 1% Ointment is a bacterial protein synthesis inhibitor belonging to a class of compounds called pleuromutilins. These compounds inhibit the initiation of protein synthesis by binding to a specific site on the 50S subunit of bacterial ribosome (domain V of 23S rRNA). This binding site involves ribosomal protein L3 and is in the region of the ribosomal P site and peptidyl transferase center. By virtue of binding to this site, pleuromutilins inhibit peptidyl transfer, block P-site interactions, and prevent the normal formation of active 50S ribosomal subunits.
Dosage
Retabac 1% Ointment dosage
Apply a thin layer of Retabac 1% Ointment to the affected area (up to 100 cm2 in total area in adults or 2% total body surface area in pediatric patients aged 9 months or older) twice daily for 5 days.
The treated area may be covered with a sterile bandage or gauze dressing if desired.
Side Effects
Side effects: Headache, pyrexia, pruritus, eczema, diarrhoea. Application site irritation, pain, erythema, contact dermatitis.
Adverse effects: Application site irritation (<2% of patients may experience).
Precaution
In the event of sensitization or severe local irritation, usage should be discontinued. Not intended for ingestion or for oral, intranasal, ophthalmic, or intravaginal use.
Interaction
The effect of concurrent application of Retabac 1% Ointment and other topical products to the same area of skin has not been studied.
Food Interaction
No interactions found.Pregnancy & Breastfeeding use
Pregnancy Category B. It is not known whether Retabac 1% Ointment is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when this product is administered to a nursing woman.
Contraindication
Hypersensitivity.
Storage Condition
Store in a cool (below 25° C)and dry place protected from light. Keep out of the reach of children.
Innovators Monograph
You find simplified version here Retabac 1% Ointment
Retabac 1% Ointment contains Retapamulin see full prescribing information from innovator Retabac 1% Ointment Monograph, Retabac 1% Ointment MSDS, Retabac 1% Ointment FDA label
FAQ
What is Retabac 1% Ointment used for?
Retabac 1% Ointment is used to treat impetigo (a skin infection caused by bacteria) in children and adults.Retabac 1% Ointment is in a class of medications called antibacterials.
How safe is Retabac 1% Ointment?
Topical Retabac 1% Ointment is effective and safe in the treatment of primary impetigo.
How does Retabac 1% Ointment work?
Retabac 1% Ointment works by killing and stopping the growth of bacteria on the skin.
What are the common side effects of Retabac 1% Ointment?
Common side effects of Retabac 1% Ointment are include:
- irritation at the in the place where you applied the ointment
- blisters
- burning
- redness
- swelling
- oozing from the place where you applied the ointment
- itching
- diarrhea
- headache
Is Retabac 1% Ointment safe during breastfeeding?
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women.
Is Retabac 1% Ointment safe during pregnancy?
exposure to the breastfeeding infant is likely to be negligible since minimal systemic exposure is observed in adults.
How long should I stay on Retabac 1% Ointment?
Retabac 1% Ointment is usually recommended that you continue on the treatment for at least 12 months. This is 12 months after you feel quite well again, not 12 months after you first started the medicine.
What kind of antibiotic is Retabac 1% Ointment?
Retabac 1% Ointment is in a new class of antibiotics called pleuromutilins.
Who should not take Retabac 1% Ointment?
Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.
What happens if I miss a dose of Retabac 1% Ointment?
Apply the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not apply two doses at one time.
What happens if I overdose?
An overdose of Retabac 1% Ointment topical is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed Retabac 1% Ointment.
What should I avoid while using Retabac 1% Ointment topical?
Impetigo is highly contagious and spreads easily from person to person. Avoid sharing personal items such as towels, washcloths, or razors with other people if you are infected with impetigo. Use a clean towel and washcloth each time you bathe to keep from reinfecting your own skin.
Avoid getting this medication in your eyes, nose, or mouth, or inside your vagina. If this does happen, rinse with water.
How should Retabac 1% Ointment used?
Retabac 1% Ointment comes as an ointment to be applied in a thin layer to the skin. Retabac 1% Ointment is usually used two times a day for 5 days. Apply Retabac 1% Ointment at around the same times every day. .
