Rheinanthrone
Rheinanthrone Uses, Dosage, Side Effects, Food Interaction and all others data.
Rheinanthrone is the active metabolite of senna glycoside Sennosides known for its laxative effect . It is commonly produced by plants of the Rheum species .
Rheinanthrone stimulates peristalsis and increases fecal water content to increase the movement of feces through the large intestine .
| Trade Name | Rheinanthrone |
| Generic | Rheinanthrone |
| Type | |
| Formula | C15H10O5 |
| Weight | Average: 270.2369 Monoisotopic: 270.05282343 |
| Groups | Experimental |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
No approved indication.
How Rheinanthrone works
Rheinanthrone appears to increase macrophage expression of cyclooxygenase 2 (COX2) which increases production of prostaglandin E2 (PGE2) . This increase in PGE2 is associated with a subsequent decrease in aquaporin 3 expression. The decreased expression of aquaporin 3 likely restricts reabsorption of water in the large intestine resulting in the laxative effect of rheinanthrone. Rheinanthrone also appears to stimulate peristalsis in the large intestine dependent on contact with the mucosal epithelium .
Elimination Route
About 10% of rheinanthrone is absorbed from the gut .
Elimination Route
2.8% of rheinanthrone is excreted in urine and 95% is excreted in feces .
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