RHu GM-CSF

RHu GM-CSF Uses, Dosage, Side Effects, Food Interaction and all others data.

RHu GM-CSF is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.

RHu GM-CSF is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.

Table Of contents

• RHu GM-CSF
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	RHu GM-CSF
Availability	Prescription only
Generic	Sargramostim
Sargramostim Other Names	rGM-CSF, rHu GM-CSF, Sargramostim
Related Drugs	fluconazole, Diflucan, cisplatin, Neulasta, Promacta, filgrastim, Zarxio, Neupogen, pegfilgrastim, eltrombopag
Type
Formula	C639H1006N168O196S8
Weight	14434.5 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

RHu GM-CSF is a modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.

For the treatment of cancer and bone marrow transplant

RHu GM-CSF is also used to associated treatment for these conditions: Bone Marrow Suppression, Delayed engraftment, Graft Failure, Neutropenia, Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis therapy

How RHu GM-CSF works

RHu GM-CSF binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils

Food Interaction

No interactions found.

RHu GM-CSF Drug Interaction

Unknown: amphotericin b lipid complex, isotretinoin, tocilizumab, corticotropin, alteplase, loxapine, fluticasone / salmeterol, theophylline, ketotifen ophthalmic, aluminum hydroxide, testosterone, umeclidinium / vilanterol, dolasetron, hydralazine, mesalamine, ethinyl estradiol / norethindrone, darbepoetin alfa, leflunomide, donepezil, benazepril

RHu GM-CSF Disease Interaction

Major: arrhythmia, fluid retention, hepatic dysfunction, leukocytosis, myeloid tumors, prematurity, renal dysfunction, respiratory symptoms

Clearance

• 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)]
• 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
• 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
• 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]

Innovators Monograph

You find simplified version here RHu GM-CSF