RHu GM-CSF

RHu GM-CSF Uses, Dosage, Side Effects, Food Interaction and all others data.

RHu GM-CSF is a human recombinant granulocyte macrophage colony-stimulating factor (GM-CSF) expressed in yeast. It is a glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein.

RHu GM-CSF is used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections.

Trade Name RHu GM-CSF
Availability Prescription only
Generic Sargramostim
Sargramostim Other Names rGM-CSF, rHu GM-CSF, Sargramostim
Related Drugs fluconazole, Diflucan, cisplatin, Neulasta, Promacta, filgrastim, Zarxio, Neupogen, pegfilgrastim, eltrombopag
Type
Formula C639H1006N168O196S8
Weight 14434.5 Da
Groups Approved, Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
RHu GM-CSF
RHu GM-CSF

Uses

RHu GM-CSF is a modified form of recombinant human granulocyte-macrophage colony stimulating factor used to increase immune cell production after myelosuppressive therapy or bone marrow transplant.

For the treatment of cancer and bone marrow transplant

RHu GM-CSF is also used to associated treatment for these conditions: Bone Marrow Suppression, Delayed engraftment, Graft Failure, Neutropenia, Mobilization of hematopoietic progenitor cells into peripheral blood for collection by leukapheresis therapy

How RHu GM-CSF works

RHu GM-CSF binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils

Food Interaction

No interactions found.

Clearance

  • 420 mL/min/m2 [Normal people with liquid LEUKINE (IV)]
  • 431 mL/min/m2 [Normal people with lyophilized LEUKINE (IV)]
  • 549 mL/min/m2 [Normal people with liquid LEUKINE (SC)]
  • 529 mL/min/m2 [Normal people with lyophilized LEUKINE (SC)]

Innovators Monograph

You find simplified version here RHu GM-CSF

*** Taking medicines without doctor's advice can cause long-term problems.
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