(S)-betaxolol
(S)-betaxolol Uses, Dosage, Side Effects, Food Interaction and all others data.
(S)-betaxolol is a beta-blocker used to lower the pressure in the eye to treat conditions such as glaucoma. It was marketed as a 0.5% ophthalmic solution of levobetaxolol hydrochloride under the trade name Betaxon but has been discontinued.
(S)-betaxolol is a selective β1 adrenergic receptor antagonist . It acts to lower intraocular pressure. Levobataxolol is condsidered to be the more active component of the betaxolol racemate.
| Trade Name | (S)-betaxolol |
| Generic | Levobetaxolol |
| Levobetaxolol Other Names | (S)-betaxolol, Levobetaxolol |
| Type | |
| Formula | C18H29NO3 |
| Weight | Average: 307.434 Monoisotopic: 307.214743798 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used in the treatment of open-angle glaucoma and ocular hypertension .
How (S)-betaxolol works
The exact mechanism by which levobetaxolol lowers intraocular pressure is not known. It it thought that antagonism of β-adrenergic receptors may reduce the production of aqueous humour stimulated via the cyclic adenosine monophosphate-protein kinase A pathway . It is also thought that the vasoconstriction produced by antagonism of β adrenergic receptors reduces blood flow to the eye and therefore the ultrafiltration responsible for aqueous humour production. β1 selective antagonists are less effective than non-selective β adrenergic receptor antagonists because β2 receptors make up the bulk of the population in the eye. They do, however, come with the benefit of reduced respiratory complications.
Elimination Route
(S)-betaxolol is applied topically to the eye but some does reach systemic circulaton with a Tmax of 3 h .
Half Life
The mean half life of levobetaxolol is 20 h .
Innovators Monograph
You find simplified version here (S)-betaxolol
