Salazopyrine E.C. Tablet, Maagsapresistente Tabletten
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten Uses, Dosage, Side Effects, Food Interaction and all others data.
The mode of action of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is still under investigation, but may be related to the anti inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten, Sulfapyridine and 5-Aminosalyclic Acid have indicated that the major therapeutic action may reside in the 5-Aminosalyclic Acid moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis.
| Trade Name | Salazopyrine E.C. Tablet, Maagsapresistente Tabletten |
| Availability | Prescription only |
| Generic | Sulfasalazine |
| Sulfasalazine Other Names | Azopyrin, Salazosulfapiridina, Salazosulfapyridine, Salazosulfapyridinum, Salicylazosulfapyridine, Sulfasalazin, Sulfasalazina, Sulfasalazine, Sulfasalazinum |
| Related Drugs | Lialda, Pentasa, Apriso, Azulfidine, Asacol, Canasa, Delzicol, Asacol HD, Dipentum, Rowasa |
| Type | |
| Formula | C18H14N4O5S |
| Weight | Average: 398.393 Monoisotopic: 398.068490268 |
| Groups | Approved |
| Therapeutic Class | Drugs for Irritable Bowel Syndrome, Drugs used for Rheumatoid Arthritis, Ulcerative Colitis |
| Manufacturer | |
| Available Country | Netherlands |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is used for:
- Rheumatoid arthritis & Juvenile arthritis: In the treatment of patients with rheumatoid arthritis and pediatiric patients with polyarticular-course juvenile rheumatoid arthritis, who have responded inadequately to salicylates or other non-steroidal anti-inflammatory drugs (NSAIDs).
- Ulcerative colitis and Crohn's Disease: As adjunct in the treatment of ulcerative colitis with the usual supportive and dietary measures. In the treatment of active Crohn's disease, especially in patients with colonic involvement.
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is also used to associated treatment for these conditions: Crohn's Disease (CD), Polyarticular juvenile rheumatoid arthritis, chronic or unspecified, Proctitis, Rheumatoid Arthritis, Severe Ulcerative Colitis, Mild Ulcerative Colitis, Moderate Ulcerative colitis
How Salazopyrine E.C. Tablet, Maagsapresistente Tabletten works
The mode of action of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.
Dosage
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten dosage
The dosage of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten tablets should be individually adjusted according to the patient's tolerance and response to the treatment and taken in evenly divided doses preferably after meals.
Adult dose for crohn’s disease: 500 mg orally 2 to 4 times a day with food.
Pediatric use (6 years or older) for Ulcerative Colitis: The initial dose 40 to 60 mg/kg/day orally divided into 3 to 6 doses.
Adultdose for rheumatoid arthritis: 2 g daily in two evenly divided doses. It is advisable to initiate therapy with a lower dosage e.g. 0.5 to 1.0 g daily, to reduce possible gastrointestinal intolerance. A suggested dosing schedule is given bellow:
- First week: One tablet in theevening
- Secondweek: One tabletin the morning &One tabletin the evening
- Thirdweek:One tabletin the morning & two tabletin the evening
- Forthweek: Two tabletin the morning &two tabletin the evening
In case of rheumatoid arthritis 6 years or older: initial dose 10 mg/kg/day orally in 2 equally divided doses.
Juvenile rheumatoid arthritis-polyarticular course: Children 6 years of age and older: 30 to 50 mg/kg/day in two evenly divided doses. Typically the maximum dose is 2 g per day.
For other indications:
Initial therapy:
- Adults: 3 to 4 g daily in divided doses with dosage intervals not exceeding eight hours. It may be advisable to initiate therapy with a lower dosage e.g. 1 to 2 g daily to reduce possible gastrointestinal intolerance.
- Children 6 years of age and older: 40 to 60 mg/kg/day in to 3 to 6 divided doses.
Maintenance therapy:
- Adults: 2 g daily.
- Children 6 years of age and older: 30 mg/kg/day in 4 divided doses.
Side Effects
The common adverse reactions are anorexia, headache, nausea, vomiting, gastric distress, dyspepsia, abdominal pain, dizziness, apparently reversible oligospermia etc.
Precaution
Hepatic/renal impairment, G6PD deficiency, allergic bronchial asthma, lactation.
Interaction
Reduced absorption of folic acid and digoxin has been reported when those agents were administered concomitantly with sulfasalazine.
Food Interaction
- Drink plenty of fluids. Inadequate fluid intake is associated with crystalluria and stone formation.
- Take with food.
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten Drug Interaction
Moderate: celecoxibUnknown: aspirin, diphenhydramine, duloxetine, etanercept, omega-3 polyunsaturated fatty acids, cyclobenzaprine, adalimumab, pregabalin, metoprolol, esomeprazole, acetaminophen / hydrocodone, hydroxychloroquine, montelukast, levothyroxine, acetaminophen, cyanocobalamin, ascorbic acid, cholecalciferol, cetirizine
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten Disease Interaction
Major: colitis, intestinal obstruction, urinary obstruction, hematologic toxicity, hypersensitivity reactions, liver disease, porphyria, renal dysfunctionModerate: renal dysfunction, folate deficiency, G6PD deficiency, crystalluria
Volume of Distribution
- 7.5 ± 1.6 L
Half Life
5-10 hours
Clearance
- 1 L/h [IV administration]
Elimination Route
The majority of 5-ASA stays within the colonic lumen and is excreted as 5-ASA and acetyl-5-ASA with the feces.
Pregnancy & Breastfeeding use
Use in pregnancy: Pregnancy category B. This drug should be used during pregnancy only if clearly needed.
Use in lactation: Caution should be exercised when sulfasalazine is administered to a nursing mother.
Contraindication
Hypersensitivity to Salazopyrine E.C. Tablet, Maagsapresistente Tabletten, its metabolites, sulfonamides or salicylates, patients with intestinal or urinary obstruction and porphyria.
Storage Condition
Store in a cool and dry place, protected from light.
Innovators Monograph
You find simplified version here Salazopyrine E.C. Tablet, Maagsapresistente Tabletten
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten contains Sulfasalazine see full prescribing information from innovator Salazopyrine E.C. Tablet, Maagsapresistente Tabletten Monograph, Salazopyrine E.C. Tablet, Maagsapresistente Tabletten MSDS, Salazopyrine E.C. Tablet, Maagsapresistente Tabletten FDA label
FAQ
What is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten used for?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is used to treat bowel inflammation, diarrhea, rectal bleeding, and abdominal pain in patients with ulcerative colitis, a condition in which the bowel is inflamed.
How safe is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten may cause reversible male infertility, but it is entirely safe for use during pregnancy and lactation. Overall, Salazopyrine E.C. Tablet, Maagsapresistente Tabletten has a long and impressive safety record, provided the drug is used with an awareness and appreciation of its potential pitfalls.
How does Salazopyrine E.C. Tablet, Maagsapresistente Tabletten work?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is an anti-inflammatory drug.Salazopyrine E.C. Tablet, Maagsapresistente Tabletten believed that it affects your immune system and decreases inflammation. Salazopyrine E.C. Tablet, Maagsapresistente Tabletten work by locally in the colon to decrease inflammation. It also works throughout the body by inhibiting the formation of a chemical known as prostaglandins.
What are the common side effects of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
The more common side effects of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten are include:
- decreased appetite
- headache
- nausea
- vomiting
- stomach upset and pain
- rash
- itching
- decreased sperm count (only while taking the medication)
- dizziness
Is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten safe during pregnancy?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten does not increase the risk of any complications of pregnancy or the risk of birth defects.
Is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten safe during breastfeeding?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is considered safe to use while you are breastfeeding, unless the baby is premature or at risk of jaundice.
Can I drink alcohol with Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
There's no particular reason to avoid alcohol while on Salazopyrine E.C. Tablet, Maagsapresistente Tabletten. However, it's recommended that people try to keep well within the recommended limits for alcohol. This limit is 14 units a week for women and men.
How quickly does Salazopyrine E.C. Tablet, Maagsapresistente Tabletten work?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten start to work could be at least 12 weeks before you notice any effects. You shouldn't take Salazopyrine E.C. Tablet, Maagsapresistente Tabletten if you're known to have an allergy to salicylates.
When is the best time to take Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
It is best to take Salazopyrine E.C. Tablet, Maagsapresistente Tabletten right after meals, at evenly spaced times throughout the day and night. Try not to let more than 8 hours go by between doses, even at night.
Does Salazopyrine E.C. Tablet, Maagsapresistente Tabletten cause weight gain?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten can causes weight gain also with other side effects.
Is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten a steroid?
No, Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is not a steroid and is actually considered a "steroid-sparing" medication.
How long can I stay on Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten takes time to work. Most patients start to feel the positive effects of at 4-8 weeks, with maximum benefit at 3-6 months.
Who should not take Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
If you have or have ever had asthma, kidney or liver disease, porphyria, blood problems, or blockage in your intestine or urinary tract you should not use Salazopyrine E.C. Tablet, Maagsapresistente Tabletten.
Does Salazopyrine E.C. Tablet, Maagsapresistente Tabletten cause hair loss?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten may not causes hair loss.
Does Salazopyrine E.C. Tablet, Maagsapresistente Tabletten reduce inflammation?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten works inside the bowels by helping to reduce the inflammation and other symptoms of the disease.
Is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten bad for my liver?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten has been linked to cases of acute liver failure, particularly with hepatocellular patterns of injury.
Can Salazopyrine E.C. Tablet, Maagsapresistente Tabletten affect my eyes?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is generally considered safe and well tolerated. There has been a report of peripheral facial nerve palsy and blurred near vision in association with Salazopyrine E.C. Tablet, Maagsapresistente Tabletten treatme.
How does Salazopyrine E.C. Tablet, Maagsapresistente Tabletten affect sperm?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten can decrease sperm counts and sperm motility.
How bad is Salazopyrine E.C. Tablet, Maagsapresistente Tabletten for you?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten may cause blood problems. These problems may result in a greater chance of certain infections, slow healing, and bleeding of the gums.
Can Salazopyrine E.C. Tablet, Maagsapresistente Tabletten cause high blood pressure?
found no effect of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten on blood pressure, hyperemic response, or arterial diameter.
Can Salazopyrine E.C. Tablet, Maagsapresistente Tabletten make me infertile?
These studies confirmed the preliminary report and suggest that prolonged treatment with Salazopyrine E.C. Tablet, Maagsapresistente Tabletten may universally depress semen quality and cause reversible infertility.
What happens if I miss a dose?
If you forget to take a dose of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten, take Salazopyrine E.C. Tablet, Maagsapresistente Tabletten as soon as you remember. If it is almost time for your next scheduled dose, take only your next dose. Do not take two doses of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten at once.
What happens if I overdose of Salazopyrine E.C. Tablet, Maagsapresistente Tabletten?
Overdose symptoms may include vomiting, stomach pain, drowsiness, or seizure.
How long does it take for Salazopyrine E.C. Tablet, Maagsapresistente Tabletten to leave my body?
Salazopyrine E.C. Tablet, Maagsapresistente Tabletten is safe to just stop Salazopyrine E.C. Tablet, Maagsapresistente Tabletten you do not need to slowly reduce the dose. However, keep in mind, if you were gaining any benefit, it will usually take at least 6 weeks to lose it.
