Secobarbitone
Secobarbitone Uses, Dosage, Side Effects, Food Interaction and all others data.
Secobarbitone (marketed by Eli Lilly and Company under the brand names Seconal and Tuinal) is a barbiturate derivative drug with anaesthetic, anticonvulsant, sedative and hypnotic properties. It is commonly known as quinalbarbitone in the United Kingdom.
Secobarbitone, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
| Trade Name | Secobarbitone |
| Availability | Discontinued |
| Generic | Secobarbital |
| Secobarbital Other Names | Quinalbarbitone, Secobarbital, Secobarbitalum, Secobarbitone |
| Related Drugs | trazodone, hydroxyzine, amitriptyline, lorazepam, diazepam, melatonin, zolpidem, promethazine, diphenhydramine, fentanyl |
| Type | |
| Formula | C12H18N2O3 |
| Weight | Average: 238.2829 Monoisotopic: 238.131742452 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Secobarbitone is a barbiturate used for the short-term treatment of insomnia.
For the Short-term treatment of intractable insomnia for patients habituated to barbiturates
Secobarbitone is also used to associated treatment for these conditions: Insomnia, Preanesthetic medication therapy
How Secobarbitone works
Secobarbitone binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Toxicity
Symptoms of an overdose typically include sluggishness, incoordination, difficulty in thinking, slowness of speech, faulty judgment, drowsiness or coma, shallow breathing, staggering, and in severe cases coma and death.
Food Interaction
- Avoid alcohol. Taking with alcohol may cause additive CNS depression.
- Take on an empty stomach. This may increase the rate of absorption.
Secobarbitone Alcohol interaction
[Major] GENERALLY AVOID:
Concurrent acute use of barbiturates and ethanol may result in additive CNS effects,
including impaired coordination, sedation, and death.
Tolerance of these agents may occur with chronic use.
The mechanism is related to inhibition of microsomal enzymes acutely and induction of hepatic microsomal enzymes chronically.
The combination of ethanol and barbiturates should be avoided.
Secobarbitone Hypertension interaction
[Major] The intravenous administration of barbiturates may produce severe cardiovascular reactions such as bradycardia, hypertension, or vasodilation with fall in blood pressure, particularly during rapid infusion.
Parenteral therapy with barbiturates should be administered cautiously in patients with hypertension, hypotension, or cardiac disease.
The intravenous administration of barbiturates should be reserved for emergency treatment of acute seizures or for anesthesia.
Secobarbitone Drug Interaction
Major: acetaminophen / oxycodoneModerate: aripiprazole, zolpidem, diphenhydramine, olmesartan, methohexital, clonazepam, mirtazapine, ramelteon, levothyroxine, diazepam, alprazolam, cetirizineUnknown: aspirin, amphetamine / dextroamphetamine, mannitol, amoxicillin / clavulanate, flax, esomeprazole, lisdexamfetamine
Elimination Route
Barbiturates are metabolized primarily by the hepatic microsomal enzyme system, and the metabolic products are excreted in the urine and, less commonly, in the feces.
Innovators Monograph
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