Sim-12

Sim-12 Uses, Dosage, Side Effects, Food Interaction and all others data.

Sim-12 is one of the active forms of vitamin B12 that is also known as adenosylcobalamin or dibencozide. This drug is available as a nutritional supplement to prevent vitamin B12 deficiency.

Vitamin B12 is a collective term for these variously substituted corrinoids. The principal biochemical participants are two coenzyme forms of Vitamin B12 that are produced and activated in two separate cellular compartments: methylcobalamin in the cytosol and adenosylcobalamin in the mitochondria .

Vitamin B12 (cyancobalamin, Cbl) has two active co-enzyme forms, methylcobalamin (MeCbl) and adenosylcobalamin (AdCbl). There has been a shift in the treatment of vitamin B12 deficiency such that MeCbl is being extensively used and promoted. This exists despite the fact that both MeCbl and AdCbl are necessary for life and have vastly different metabolic fates and functions. MeCbl is mainly involved along with folate in hematopoiesis and the growth of the brain during childhood. Deficiency of AdCbl disturbs the carbohydrate, fat and amino-acid metabolism, and therefore interferes with the formation of myelin. It is therefore important to treat vitamin B12 deficiency with a combination of MeCbl and AdCbl or hydroxocobalamin or cobalamin .

Table Of contents

• Sim-12
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Sim-12
Generic	Cobamamide
Cobamamide Other Names	Adenosylcob(III)alamin, Adenosylcobalamin, cobamamida, Cobamamide, cobamamidum, Cobanamida, Coenzyme B-12, Coenzyme B12, Vitamin B12 coenzyme
Type
Formula	C72H100CoN18O17P
Weight	Average: 1579.5818 Monoisotopic: 1578.65834557
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Sim-12 is an ingredient found in a variety of supplements and vitamins.

Sim-12 is also used to associated treatment for these conditions: Malnutrition, Vitamin B12 Deficiency, Weight Loss, Nutrition

Toxicity

Acute oral toxicity (LD50): 5000 mg/kg in the guinea pig [L20502]

Food Interaction

No interactions found.

Innovators Monograph

You find simplified version here Sim-12