Sodium Citrate and Citric Acid
Sodium Citrate and Citric Acid Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium citrate is the sodium salt of citric acid. It is white, crystalline powder or white, granular crystals, slightly deliquescent in moist air, freely soluble in water,practically insoluble in alcohol. Like citric acid, it has a sour taste.From the medical point of view, it is used as alkalinizing agent. It works by neutralizing excess acid in the blood and urine. It has been indicated for the treatment of metabolic acidosis.
Citrate prevents activation of the clotting cascade by chelating calcium ions. Citrate neutralizes acid in the stomach and urine, raising the pH .
| Trade Name | Sodium Citrate and Citric Acid |
| Generic | Sodium citrate + citric acid monohydrate |
| Type | Oral solution |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | United States |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Citric Acid Monohydrate is indicated for the management of dry cough.Sodium citrate is an ingredient used for the anticoagulation of whole blood as part of automated apheresis procedures.
Used as an anticoagulant during plasmophoresis as well as a neutralizing agent in the treatment of upset stomach and acidic urine .
Sodium Citrate and Citric Acid is also used to associated treatment for these conditions: Acidosis, Allergic cough, Allergies, Asthma, Asthma Chronic, Cough, Common Cold, Cough, Coughing caused by Bronchitis, Dehydration, Gouty Arthritis, Heartburn, Metabolic Acidosis, Phlegm, Airway secretion clearance therapy, Oral rehydration therapy, Plasmapheresis, Urine alkalinization therapy, Fluid and electrolyte maintenance therapy, Irrigation during surgical procedures, Irrigation of the ocular surface therapy
How Sodium Citrate and Citric Acid works
Citrate chelates free calcium ions preventing them from forming a complex with tissue factor and coagulation factor VIIa to promote the activation of coagulation factor X . This inhibits the extrinsic initiation of the coagulation cascade. Citrate may also exert an anticoagulant effect via a so far unknown mechanism as restoration of calcium concentration does not fully reverse the effect of citrate . Citrate is a weak base and so reacts with hydrochloric acid in the stomach to raise the pH. It it further metabolized to bicarbonate which then acts as a systemic alkalizing agent, raising the pH of the blood and urine . It also acts as a diuretic and increases the urinary excretion of calcium.
Dosage
Sodium Citrate and Citric Acid dosage
1-5 years: 5 ml upto 4 times daily6-12 years: 10 ml upto 4 times daily>12 years & Adults: 20 ml upto 3-4 times dailySide Effects
There are no known side effects from using this medicine when used as directed. If taken excessively above the stated dose, glycerol present in the medicine may cause headache, stomach upset and diarrhea.Toxicity
Overdose toxicity is mainly due to alkalosis as well as tetany or depressed heart function due to lack of free calcium .
Precaution
Patients with rare hereditary problems of fructose intolerance, glucose-galactose malabsorption or sucrase-isomaltase insufficiency should not take this medicine.Interaction
No drug-drug interaction has been found.Volume of Distribution
19-39L .
Elimination Route
Tmax of 98-130min .
Half Life
18-54 min
Clearance
Total clearance of 313-1107mL/min .
Elimination Route
Largely eliminated through hepatic metabolism with very little cleared by the kidneys .
Pregnancy & Breastfeeding use
There are no or limited amount of data from the use of Citric Acid Monohydrate in pregnant women. There is insufficient information on the excretion of Citric Acid Monohydrate & its metabolites in human milk.Contraindication
It is contraindicated for the hypersensitivity to any of the ingredients of this medicine.Storage Condition
Keep in a cool and dry place, away from light. Keep out of the reach of children.Innovators Monograph
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