Stanate

Stanate Uses, Dosage, Side Effects, Food Interaction and all others data.

Stanate is a competitive heme oxygenase (HO) inhibitor being developed by InfaCare, a subsidiary of WellSpring Pharmaceuticals, for the prevention of hyperbilirubinemia in infants at risk of developing jaundice.

Stanate is a chemical compound being investigated for use as a medicament in the treatment of infant jaundice. Stanate is also known to inhibit heme metabolism in mammals, to control the rate of tryptophan metabolism in mammals, and to increase the rate at which heme is excreted by mammals.

Trade Name Stanate
Generic Stannsoporfin
Stannsoporfin Other Names Stannsoporfin, Tin mesoporphyrin
Type
Formula C34H36Cl2N4O4Sn
Weight Average: 754.3
Monoisotopic: 754.113563
Groups Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Stanate
Stanate

Uses

Investigated for use/treatment in liver disease, metabolic disease, and pediatric indications.

How Stanate works

Kernicterus is attributed to high levels of bilirubin, a by-product of heme metabolism. Bilirubin is a bile pigment, which is normally eliminated from the body after conversion into a water-soluble form by the liver. Stanate's mechanism of action specifically inhibits the enzyme that blocks the conversion of heme into bilirubin.

Elimination Route

Not absorbed orally

Half Life

3.8 hours following i.v. administration of 1 mumole per kg body weight

Innovators Monograph

You find simplified version here Stanate

*** Taking medicines without doctor's advice can cause long-term problems.
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