Sulfadoxina Uses, Dosage, Side Effects and more
A long acting sulfonamide that is used, usually in combination with other drugs, for respiratory, urinary tract, and malarial infections.
Sulfadoxina helps inhibit the enzyme dihydropteroate synthetase which is an enzyme necessary in the conversion of PABA to folic acid. As folic acid is vital to the synthesis, repair, and methylation of DNA which is vital to cell growth in Plasmodium falciparum. With this vital nutrient lacking, the parasite has difficulty in reproducing.
| Attribute | Details |
|---|---|
| Trade Name | Sulfadoxina |
| Availability | Discontinued |
| Generic | Sulfadoxine |
| Sulfadoxine Other Names | Sulfadoxina, Sulfadoxine, Sulfadoxinum, Sulforthomidine, Sulphadoxine, Sulphormethoxine |
| Type | |
| Formula | C12H14N4O4S |
| Weight | Average: 310.329 Monoisotopic: 310.073575646 |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | January 7, 2025 at 1:49 am |
Uses
Sulfadoxina is a long acting sulfonamide used for the treatment or prevention of malaria.
Sulfadoxina is used in combination with pyrimethamine for the treatment or prevention of malaria. It can also be used to treat various infections in livestock as well. Sulfadoxina and pyrimethamine is indicated for the treatment of Plasmodium falciparum malaria in those patients in whom chloroquine resistance is suspected.
Sulfadoxina is also used to associated treatment for these conditions: Plasmodium Infections
How Sulfadoxina works
Sulfadoxina is a sulfa drug, often used in combination with pyrimethamine to treat malaria. This medicine may also be used to prevent malaria in people who are living in, or will be traveling to, an area where there is a chance of getting malaria. Sulfadoxina targets Plasmodium dihydropteroate synthase and dihydrofolate reductase. Sulfa drugs or Sulfonamides are antimetabolites. They compete with para-aminobenzoic acid (PABA) for incorporation into folic acid. The action of sulfonamides exploits the difference between mammal cells and other kinds of cells in their folic acid metabolism. All cells require folic acid for growth. Folic acid (as a vitamin) diffuses or is transported into human cells. However, folic acid cannot cross bacterial (and certain protozoan) cell walls by diffusion or active transport. For this reason bacteria must synthesize folic acid from p-aminobenzoic acid.
Food Interaction
- Take after a meal. Taking sulfadoxine with food, may reduce gastrointestinal irritation.
- Take with a full glass of water.
Drug Interaction
Moderate: phenytoinUnknown: aspirin, epinephrine, amoxicillin, RHO Immunoglobulin , mesalamine, azithromycin, ciprofloxacin, dexamethasone, dextran, low molecular weight, pentosan polysulfate sodium, human papillomavirus vaccine, heparin, diatrizoate, ibuprofen, diphenhydramine / ibuprofen, ipratropium, scopolamine ophthalmic, iodine / potassium iodide, acetaminophen
Disease Interaction
Major: colitis, hematologic toxicity, hypersensitivity reactions, liver disease, porphyria, renal dysfunctionModerate: crystalluria, urinary obstruction
