Sulindac Sulfone

Sulindac Sulfone Uses, Dosage, Side Effects, Food Interaction and all others data.

Table Of contents

• Sulindac Sulfone
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Sulindac Sulfone
Generic	Exisulind
Exisulind Other Names	Exisulind, Sulindac sulfone
Type
Formula	C20H17FO4S
Weight	Average: 372.41 Monoisotopic: 372.083158364
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Investigated for use/treatment in adenomatous polyposis coli, lung cancer, prostate cancer, colon polyps, Barrett's esophagus disease, and pediatric indications.

How Sulindac Sulfone works

Sulindac Sulfone is a sulindac derivative of a class of compounds called selective apoptotic anti-neoplastic drugs (SAANDs), which inhibit the enzyme cyclic guanosine monophosphodiesterase (cGMP - PDE). Sulindac Sulfone is specific for apoptotic effects in precancerous and cancerous colorectal cells due to their overexpression of cGMP. Sustained elevation of cGMP and protein kinase G (PKG) activation may be also implicated in the induction of apoptosis by Sulindac Sulfone.

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