Surital

Surital Uses, Dosage, Side Effects, Food Interaction and all others data.

A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)

Surital, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.

Trade Name Surital
Generic Thiamylal
Thiamylal Other Names Thiamylal
Type
Formula C12H18N2O2S
Weight Average: 254.349
Monoisotopic: 254.10889852
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Surital
Surital

Uses

Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state.

How Surital works

Surital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.

Toxicity

Intravenous LD50 in rat is 51 mg/kg.

Elimination Route

Rapidly absorbed (high lipid solubility).

Half Life

Although no studies have been performed on humans, the half-life in cats is 14.3 hours.

Innovators Monograph

You find simplified version here Surital

*** Taking medicines without doctor's advice can cause long-term problems.
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