Thiamylal
Thiamylal Uses, Dosage, Side Effects, Food Interaction and all others data.
A barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)
Thiamylal, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia.
| Trade Name | Thiamylal |
| Generic | Thiamylal |
| Thiamylal Other Names | Thiamylal |
| Type | |
| Formula | C12H18N2O2S |
| Weight | Average: 254.349 Monoisotopic: 254.10889852 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Used for the production of complete anaesthesia of short duration, for the induction of general anaesthesia, and for inducing a hypnotic state.
How Thiamylal works
Thiamylal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Toxicity
Intravenous LD50 in rat is 51 mg/kg.
Elimination Route
Rapidly absorbed (high lipid solubility).
Half Life
Although no studies have been performed on humans, the half-life in cats is 14.3 hours.
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