Synterin

Synterin Uses, Dosage, Side Effects, Food Interaction and all others data.

A pyrrolidinylmethyl tetracycline.

Table Of contents

• Synterin
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Synterin
Generic	Rolitetracycline
Rolitetracycline Other Names	Rolitetraciclina, Rolitetracycline, Rolitetracyclinum
Type
Formula	C27H33N3O8
Weight	Average: 527.5662 Monoisotopic: 527.226765047
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Synterin is a broad-spectrum tetracycline antibiotic used in cases needing high concentrations or when oral administration is impractical.

Synterin is a broad-spectrum antibiotic used in cases needing high concentrations or when oral administration is impractical.

How Synterin works

Synterin is a semisynthetic broad-spectrum tetracycline antibiotic used especially for parenteral administration in cases requiring high concentrations or when oral administration is impractical. Synterin passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.

Toxicity

Symptoms of overdose include anorexia, nausea, diarrhoea, glossitis, dysphagia, enterocolitis and inflammatory lesions (with monilial overgrowth) in the anogenital region, skin reactions such as maculopapular and erythematous rashes, exfoliative dermatitis, photosensitivity, hypersensitivity reactions such as urticaria, angioneurotic oedema, anaphylaxis, anaphyl-actoid purpura, pericarditis, and exacerbation of systemic lupus erythematosus, benign intracranial hypertension in adults disappearing on discontinuation of the medicine, haematologic abnormalities such as haemolytic anaemia, thrombocytopenia, neutropenia, and eosinophilia. LD₅₀=262 mg/kg (I.P. in rat).

Food Interaction

• Avoid milk and dairy products. Dairy products contain cations such as calcium which may interfere with the absorption of rolitetracycline.

Innovators Monograph

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