Tang Ren Xin Uses, Dosage, Side Effects and more

A broad-spectrum 6-fluoronaphthyridinone antibacterial agent (fluoroquinolones) structurally related to nalidixic acid.

Tang Ren Xin is a quinolone/fluoroquinolone antibiotic. Tang Ren Xin is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Tang Ren Xin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. Tang Ren Xin may be active against pathogens resistant to drugs that act by different mechanisms.

Trade Name	Tang Ren Xin
Availability	Discontinued
Generic	Enoxacin
Enoxacin Other Names	Enoxacin, Enoxacina, Énoxacine, Enoxacino, Enoxacinum
Related Drugs	amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, ceftriaxone, levofloxacin, Augmentin, amoxicillin / clavulanate
Type
Formula	C15H17FN4O3
Weight	Average: 320.3189 Monoisotopic: 320.128468635
Protein binding	Enoxacin is approximately 40% bound to plasma proteins in healthy subjects and is approximately 14% bound to plasma proteins in patients with impaired renal function.
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	China
Last Updated:	January 7, 2025 at 1:49 am

Uses

For the treatment of adults (≥18 years of age) with the following infections caused by susceptible strains of the designated microorganisms: (1) uncomplicated urethral or cervical gonorrhea due to Neisseria gonorrhoeae, (2) uncomplicated urinary tract infections (cystitis) due to Escherichia coli, Staphylococcus epidermidis, or Staphylococcus saprophyticus, and (3) complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus epidermidis, or Enterobacter cloacae.

How Tang Ren Xin works

Tang Ren Xin exerts its bactericidal action via the inhibition of the essential bacterial enzyme DNA gyrase (DNA Topoisomerase II).

Tang Ren Xin multivitamins interaction

[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.

Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.

The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.

The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.

When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.

When coadministered with Suprep Bowel Prep (magnesium

Please consult individual product labeling for specific recommendations.

Tang Ren Xin Drug Interaction

Major: warfarin, warfarinModerate: calcium / vitamin d, calcium / vitamin dMinor: torsemide, torsemide, furosemide, furosemideUnknown: spironolactone, spironolactone, amoxicillin / clavulanate, amoxicillin / clavulanate, glucose, glucose, albuterol / ipratropium, albuterol / ipratropium, haloperidol, haloperidol, heparin flush, heparin flush

Tang Ren Xin Disease Interaction

Major: CNS disorders, myasthenia gravis, peripheral neuropathy, tendonitis

Elimination Route

Rapidly absorbed following oral administration, with an absolute oral bioavailability of approximately 90%.

Half Life

Plasma half-life is 3 to 6 hours.

Innovators Monograph