Tauroursodeoxycholate
Tauroursodeoxycholate Uses, Dosage, Side Effects, Food Interaction and all others data.
Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is the more abundant naturally produced bile acid in humans. Tauroursodeoxycholate, on the other hand, is produced abundantly in bears and has been used for centuries as a natural remedy in some Asian countries. It is approved in Italy and Turkey for the treatment of cholesterol gallstones and is an investigational drug in China, Unites States, and Italy. Tauroursodeoxycholate is being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis. The only completed clinical trial thus far is a phase III clinical trial comparing tauroursodeoxycholic acid and ursofalk in PBC adult patients, but as of June 2013 no results of this trial have been published.
| Trade Name | Tauroursodeoxycholate |
| Generic | Tauroursodeoxycholic acid |
| Tauroursodeoxycholic acid Other Names | Tauroursodeoxycholate, Tauroursodesoxycholic acid, TUDCA, Ursodeoxycholyltaurine |
| Type | |
| Formula | C26H45NO6S |
| Weight | Average: 499.71 Monoisotopic: 499.296759347 |
| Groups | Experimental, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tauroursodeoxycholate is the taurine conjugate of ursodeoxycholic acid with antiapoptotic and ER stress response dampening effects used in some countries to treat gallstones. It is also being investigated for a wide variety of other conditions.
Used in the treatment of cholesterol gallstones. Tauroursodeoxycholate is also being investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis.
Tauroursodeoxycholate is also used to associated treatment for these conditions: Stone - Biliary, Gallstone formation
How Tauroursodeoxycholate works
Tauroursodeoxycholate is the more hydrophilic form of ursodeoxycholic acid, which is naturally produced in the body. In patients with properly functioning gallbladders, both of these bile acids inhibit liver cholesterol secretion and synthesis as well as intestinal cholesterol absorption allowing for the promotion of cholesterol gallstone dissolution. The mechanism of action of tauroursodeoxycholic acid in the other conditions is still being investigated.
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