Technetium (99mTc) Red Blood Cells
Technetium (99mTc) Red Blood Cells Uses, Dosage, Side Effects, Food Interaction and all others data.
Technetium (99mTc) Red Blood Cells is a radiopharmaceutical diagnostic agent that is intravenously administered to be used in blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of sites of gastrointestinal bleeding. It is clinically useful in early detection and localization of bleeding sites, and preoperative diagnosis of hemangioma . Autologous red blood cells are radiolabeled with sodium pertechnetate Tc 99m in the reaction vial. Radiolabeled red blood cells are re-injected intravenously into the patient for gamma scintigraphic imaging . It is suggested that in vitro labelling improves the heart-to-background ratio during imaging .
Technetium (99mTc) Red Blood Cells are diagnostic agents that are distributed within the circulation to assess the vascular nature of hemangiomas and diagnosis of venous occlusion . Blood abnormalities can be detected during gamma scintigraphic imaging.
| Trade Name | Technetium (99mTc) Red Blood Cells |
| Generic | Technetium Tc-99m red blood cells |
| Technetium Tc-99m red blood cells Other Names | Technetium (99mTc) red blood cells, Technetium Tc 99m red blood cells, Technetium Tc 99m-labeled red blood cells, Technetium Tc-99m red blood cell, Technetium Tc-99m red blood cell human |
| Type | |
| Protein binding | Of the total technetium Tc 99m retained in the whole blood pool 24 hours after administration, 95% remains bound to the red blood cells . |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Technetium (99mTc) Red Blood Cells is a diagnostic radiopharmaceutical agent used for blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of sites of gastrointestinal bleeding.
Indicated for blood pool imaging, including cardiac first pass and gated equilibrium imaging and for detection of sites of gastrointestinal bleeding .
Technetium (99mTc) Red Blood Cells is also used to associated treatment for these conditions: Gastrointestinal Bleeding
How Technetium (99mTc) Red Blood Cells works
Autologous red blood cells (RBC) are collected from the patient and put into the reaction vial for radiolabeling, followed by anticoagulation with heparin or Anticoagulant Citrate Dextrose Solution (ACD). In the reaction vial, stannous ion diffuses across the RBC membrane and accumulates intracellularly. Sodium hypochlorite, which does not cross the RBC membrane, is then added to the reaction vial to oxidize the extracellular stannous ion. Finally, sodium pertechnetate Tc 99m is added to the oxidized reaction vial to diffuse across the red blood cell membrane and be reduced by the intracellular stannous ion. Upon reduction, Tc 99m cannot diffuse out of the RBC. Technetium Tc 99m-labeled red blood cells are injected again into the patient for gamma scintigraphic imaging .
Toxicity
No long term animal studies have been performed to evaluate carcinogenic or mutagenic potential or to determine the effects on male or female fertility .
Volume of Distribution
Following intravenous injection, the technetium Tc 99m-labeled red blood cells distribute within the blood pool with an estimated volume of distribution of approximately 5.6% of bodyweight .
Half Life
Technetium Tc 99m decays by isomeric transition with a physical half-life of 6.02 hours. The technetium Tc 99m is well retained in the blood pool with an estimated biological half-life of approximately 29 hours .
Elimination Route
Approximately 25% of the injected dose is excreted in the urine in the first 24 hours .
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