Testosterone propionate
Testosterone propionate Uses, Dosage, Side Effects, Food Interaction and all others data.
Testosterone propionate is a slower releasing anabolic steroid with a short half-life. This characteristic allows the user to run short testosterone propionate cycles of 8-10 weeks as optimal peak blood plasma levels are achieved at 2-4 weeks. It is a synthetic androstane steroid derivative of testosterone in the form of 17β propionate ester of testosterone. Testosterone propionate was developed initially by Watson labs, and FDA approved on February 5, 1974. Currently, this drug has been discontinued in humans, but the vet application is still available as an OTC.
The administration of testosterone propionate can induce production of proteins related to male sexual development. On the other hand, testosterone itself present an estrogenic activity due to interaction with aromatase enzyme, thus the continuous aministration of testosterone propionate may cause the elevation of plasma estrogen. Clinical trials showed as well, a decrease in plasma LH after testosterone propionate administration.
| Trade Name | Testosterone propionate |
| Generic | Testosterone propionate |
| Testosterone propionate Other Names | Testosterone propionate |
| Type | |
| Formula | C22H32O3 |
| Weight | Average: 344.4877 Monoisotopic: 344.23514489 |
| Protein binding | Even 98% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound or bound to albumin and other proteins. |
| Groups | Approved, Investigational, Vet approved, Withdrawn |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Testosterone propionate is a slow-release anabolic steroid no longer used commonly for the treatment of androgen deficiency or promotion of anabolic effects on muscles.
Testosterone propionate is often used for muscle mass building. The original medical indication is for the treatment of androgen deficiency in male adults either in hypogonadism or andropause. Nowadays testosterone propionate is indicated for its use in heifers in order to stimulate maximal growth.
Testosterone propionate is also used to associated treatment for these conditions: Breast Cancer, Puberty, Delayed, Testosterone Deficiency, Hematomas
How Testosterone propionate works
The effects of testosterone in humans and other vertebrates occur by way of two main mechanisms: by activation of the androgen receptor (directly or as DHT), and by conversion to estradiol and activation of certain estrogen receptors. Free testosterone (T) is transported into the cytoplasm of target tissue cells, where it can bind to the androgen receptor, or can be reduced to 5alpha-dihydrotestosterone (DHT) by the cytoplasmic enzyme 5alpha-reductase. The areas of binding are called hormone response elements (HREs), and influence transcriptional activity of certain genes, producing the androgen effects.
Toxicity
Reports have showed a potential stimulation of cancerous tissue growth. The potential testosterone propionate accumulation in the body produces a high risk of edema secondaryh to water and sodium retention.
Food Interaction
No interactions found.Volume of Distribution
The registered volume of distribution for testosterone propionate is in the range of 75-120 L/kg.
Elimination Route
Testosterone propionate presents a slow absorption from the intramuscular site of administration. This slow absorption is due to the presence of the less polar ester group. The absorption rate of testosterone propionate generates a frequent injection requirement when compared with testosterone enanthate or testosterone cypionate. It presents absorption parameters of AUC and residence time of 180-210 ng h/ml and 40-60 h, respectively.
Half Life
Testosterone propionate presents a the shortest half life of all testosterone esters, being of 4.5 days. This characteristic produces a higher administration requirement.
Clearance
Testosterone propionate has a reduced clearance rate compared to testosterone. The reported clearance rate is of approximately 2000 ml/min.
Elimination Route
About 90% of a dose of testosterone given intramuscularly is excreted in the urine as glucuronic and sulfuric acid conjugates of testosterone and its metabolites. From the rest of the dose, approximately 6% of a dose is excreted in the feces, mostly in the unconjugated form.
Innovators Monograph
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