Thiam
Thiam Uses, Dosage, Side Effects, Food Interaction and all others data.
Thiam, in the form of thiamine pyrophosphate, is the coenzyme for decarboxylation of α-ketoglutaric acid. Thiam deficiency affects the peripheral nervous system, the gastrointestinal tract, and the cardiovascular system. This vitamin is necessary for the optimal growth of infants and children. Thiam is not stored in the body, and is regularly lost from tissues during short periods of deficiency. In order to maintain normal health, an adequate amount of thiamine is required every day. Deficiency of thiamine leads to fatigue, anorexia, gastrointestinal disturbance, tachycardia, irritability and neurological symptoms. Beriberi, a disease due to vitamin B1 deficiency, is common in alcoholics, in pregnant women receiving an inadequate diet, and in people with malabsorption syndrome, prolonged diarrhoea and hepatic disease.
Thiam is well absorbed from the gastrointestinal tract and widely distributed throughout the body. Thiam is rapidly absorbed from the upper small intestine. Thiam is not stored in the body to any appreciable extent. Excess ingested thiamine appears in urine as intact thiamine or as pyrimidine, which arises from degradation of the thiamine molecule. The plasma half life of thiamine is 24 hours.
Thiam is a vitamin with antioxidant, erythropoietic, cognition-and mood-modulatory, antiatherosclerotic, putative ergogenic, and detoxification activities. Thiam has been found to protect against lead-induced lipid peroxidation in rat liver and kidney. Thiam deficiency results in selective neuronal death in animal models. The neuronal death is associated with increased free radical production, suggesting that oxidative stress may play an important early role in brain damage associated with thiamine deficiency. Thiam plays a key role in intracellular glucose metabolism and it is thought that thiamine inhibits the effect of glucose and insulin on arterial smooth muscle cell proliferation. Inhibition of endothelial cell proliferation may also promote atherosclerosis. Endothelial cells in culture have been found to have a decreased proliferative rate and delayed migration in response to hyperglycemic conditions. Thiam has been shown to inhibit this effect of glucose on endothelial cells.
| Trade Name | Thiam |
| Availability | Rx and/or OTC |
| Generic | Thiamine |
| Thiamine Other Names | Aneurin, Antiberiberi factor, Thiamin, Thiamine, thiamine(1+), thiamine(1+) ion, thiaminium, Thiaminum, Tiamina, Vitamin B1 |
| Related Drugs | ferrous sulfate, folic acid, ergocalciferol, Zinc, selenium, Vitamin B1 |
| Weight | 100mg |
| Type | Tablet |
| Formula | C12H17N4OS |
| Weight | Average: 265.355 Monoisotopic: 265.112306876 |
| Protein binding | 90-94% |
| Groups | Approved, Investigational, Nutraceutical, Vet approved |
| Therapeutic Class | Vitamin-B preparations |
| Manufacturer | Millat Pharmaceuticals Limited |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Thiam is specifically used in the treatment of the various manifestations of thiamine deficiency such as Beriberi and Wernick's encephalopathy, neuritis associated with pregnancy and pellagra. Supplementary Thiam may be used prophylactically in conditions where there is low dietary intake or impaired gastro intestinal absorption of thiamine (e.g. alcohol) or where requirements are increased (pregnancy, carbohydrate rich diet).
Thiam is also used to associated treatment for these conditions: Anemia, B12 Deficiency Anemia, Beriberi, Cardiovascular Heart Disease caused by Thiamine Deficiency, Folic Acid Deficiency Anemia, Infantile Beriberi, Infection, Iron Deficiency (ID), Liver disorder, Neuritis caused by Pregnancy, Secondary anemia, Thiamine Deficiency, Vitamin Deficiency, Wernicke's encephalopathy, Nutritional supplementation, Vitamin supplementation, Dietary supplementation
How Thiam works
It is thought that the mechanism of action of thiamine on endothelial cells is related to a reduction in intracellular protein glycation by redirecting the glycolytic flux. Thiam is mainly the transport form of the vitamin, while the active forms are phosphorylated thiamine derivatives. Natural derivatives of thiamine phosphate, such as thiamine monophosphate (ThMP), thiamine diphosphate (ThDP), also sometimes called thiamine pyrophosphate (TPP), thiamine triphosphate (ThTP), and thiamine triphosphate (AThTP), that act as coenzymes in addition to their each unique biological functions.
Dosage
Thiam dosage
Prophylaxis: 3 to 10 mg daily.
Mild chronic deficiency: 10 to 25 mg daily.
Severe deficiency: 200 to 300 mg daily.
Side Effects
Vitamin B1 does not have adverse effects when given orally, but in a few fatal cases anaphylactic reactions have occurred after intravenous administration of large doses (400 mg) in sensitive patients, especially children, and in one case following an intramuscular dose of 125 mg. The risk of such reactions increases with repeated administration of the drug by parenteral route. Transient mild soreness may occur at the site of intramuscular administration
Toxicity
Thiam toxicity is uncommon; as excesses are readily excreted, although long-term supplementation of amounts larger than 3 gram have been known to cause toxicity. Oral mouse LD50 = 8224 mg/kg, oral rat LD50 = 3710 mg/kg.
Interaction
No hazardous drug interactions have been reported. Vitamin B1 acts synergistically with other vitamins of the B-complex group and its potential for causing adverse effects is considerably reduced.
Food Interaction
No interactions found.Thiam Disease Interaction
Elimination Route
Absorbed mainly from duodenum, by both active and passive processes
Pregnancy & Breastfeeding use
The drug may be given safely to neonates, children, pregnant and lactating women and elderly patients.
Contraindication
There is no absolute contraindication but the risk of anaphylaxis is increased by repeated parenteral administration. Mild allergic phenomena, such as sneezing or mild asthma are warning signs that further may give rise to anaphylactic shock. To avoid this possibility it is advisable to start a second course of injection with a dose considerably lower than that previously used. Because of the above, vitamin B1 injection should not be given intravenously except in the case of comatose patients. Once thiamine deficiency is corrected there is no need for parenteral administration or for the administration of amounts in excess of daily requirement.
Storage Condition
Thiam injection should be protected from light and moisture.
Innovators Monograph
You find simplified version here Thiam
FAQ
What is Thiam used for?
Thiam is used to treat beriberi tingling and numbness in feet and hands, muscle loss, and poor reflexes caused by a lack of Thiam in the diet and to treat and prevent Wernicke-Korsakoff syndrome tingling and numbness in hands and feet, memory loss, confusion caused by a lack of Thiam in the diet.
How safe is Thiam?
Thiam is generally safe. Very high doses may cause stomach upset.
What are the common side effects of Thiam?
Side effects of Thiam are include:
- warmth
- severe allergic reaction (anaphylaxis)
- skin discoloration
- sweating
- restlessness
- rapid swelling of the skin
- itching
- hives
- fluid in the lungs (pulmonary edema)
- weakness
- tightness of the throat
- nausea
Who should not take Thiam?
You should not use Thiam if you have ever had an allergic reaction to it.
Can I take Thiam daily?
The recommended daily amount of Thiam for adult men is 1.2 milligrams and for adult women is 1.1 milligrams.
How long should I take Thiam for?
Thiam use daily for one month. A complete and balanced diet should follow.
What happens if I stop taking Thiam?
if you stop taking Thiam it can lead to serious health conditions including beriberi and Wernicke-Korsakoff syndrome.
Is Thiam safe during pregnancy?
Thiam is generally safe to take during pregnancy.Thiam is only recommended for use during pregnancy when benefit outweighs risk.
Is Thiam good for pregnancy?
Thiam is essential during pregnancy because it supports your baby's brain development and enables you and your baby to convert carbohydrates into energy.
Is Thiam safe during breastfeeding?
Thiam is usually safe to take while you're breastfeeding. It passes into your breast milk, but it's not harmful to your baby.
When should I take Thiam?
Thiam tablets are usually taken once a day. Doses of 25-100 mg are sufficient to prevent mild deficiency. You can take the tablets at whatever time of day you find easiest to remember, either before or after meals.
What happens if I get too much of Thiam?
If I get too much of Thiam it can cause hypertension or high blood pressure.
Does Thiam increase heart rate?
Yes,Thiam may increased heart rate.
Is Thiam good for anxiety?
Thiam intake to an improvement in anxiety levels for those with generalized anxiety disorder.
Can I drink alcohol with Thiam?
It's best to avoid alcohol if you are taking Thiam for a vitamin B1 deficiency.
Does Thiam help hangovers?
Thiam can play a major role in the functioning of brain and nervous system and aid your body in getting over the hangover easily.
When should I stop taking Thiam?
If the patient has been abstinent for 6 weeks or more and has regained adequate nutritional status then should you stop taking Thiam.
What does Thiam do in the brain?
Thiam is an essential cofactor for several enzymes involved in brain cell metabolism that are required for the production of precursors for several important cell components as well as for the generation of the energy–supplying molecule ATP.
Can I drive after taking Thiam?
This medicine is not known to affect the ability to drive or use machines.If you feel you may be affected, do not drive or use machines and speak to your doctor.
Can Thiam cause headaches?
Low Thiam intake leads to increased risk of the Wernicke-Korsakoff and frequent headaches.
