Ticarcilina
Ticarcilina Uses, Dosage, Side Effects, Food Interaction and all others data.
An antibiotic derived from penicillin similar to carbenicillin in action.
Ticarcilina is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. Ticarcilina is, however, susceptible to degradation by ß-lactamases, and therefore, the spectrum of activity does not normally include organisms which produce these enzymes.
Trade Name | Ticarcilina |
Availability | Discontinued |
Generic | Ticarcillin |
Ticarcillin Other Names | Ticarcilina, Ticarcillin, Ticarcilline, Ticarcillinum |
Related Drugs | amoxicillin, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin, Augmentin |
Type | |
Formula | C15H16N2O6S2 |
Weight | Average: 384.427 Monoisotopic: 384.044977634 |
Protein binding | 45% |
Groups | Approved, Investigational, Vet approved |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Ticarcilina is a beta lactam antibiotic used to treat a variety of infections in the body.
For the treatment of bacterial infections.
Ticarcilina is also used to associated treatment for these conditions: Infection
How Ticarcilina works
Ticarcilina's principal mechanism of action revolves around its capacity to prevent the cross-linking of peptidoglycan during bacterial cell wall synthesis. Consequently, when the offending bacteria attempt to undergo cell division, cell death occurs.
Toxicity
As with other penicillins, neurotoxic reactions may arise when very high doses of ticarcillin are administered, especially in patients with impaired renal function.
Ticarcilina Hypertension interaction
[Moderate] Parenteral ticarcillin disodium contains approximately 120 to 150 mg (5.2 to 6.5 mEq) of sodium per each gram of ticarcillin activity.
The combination, ticarcillin-clavulanate, contains approximately 109 mg (4.75 mEq) of sodium per gram of total drug.
The sodium content should be considered in patients with conditions that may require sodium restriction, such as congestive heart failure, hypertension, and fluid retention.
In addition, hypokalemia has been reported rarely during therapy with ticarcillin and other extended-spectrum penicillin antibiotics, which may be particularly important to bear in mind when treating patients with low potassium reserves or fluid and electrolyte imbalance.
Clinical monitoring of electrolytes is recommended if these agents are used for prolonged periods.
Ticarcilina Drug Interaction
Unknown: aspirin, epinephrine, albumin human, amoxicillin / clavulanate, amoxicillin, cefazolin, amoxicillin / clavulanate, calcium citrate, calcium / vitamin d, ciprofloxacin, enoxaparin, sulfamethoxazole / trimethoprim, pancrelipase, meperidine, glucose, progesterone, levothyroxine, insulin isophane, acetaminophen, cholecalciferol
Ticarcilina Disease Interaction
Major: colitisModerate: coagulation abnormalities, renal dysfunction, hemodialysis, sodium/potassium
Half Life
1.1 hours
Innovators Monograph
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