Tisomycin
Tisomycin Uses, Dosage, Side Effects, Food Interaction and all others data.
Antibiotic substance produced by Streptomyces garyphalus.
Tisomycin, a broad-spectrum antibiotic, may be bactericidal or bacteriostatic, depending on its concentration at the site of infection and the susceptibility of the organism. Tisomycin works by blocking the formation of these peptidoglycans. By doing this the walls of the bacteria become weak and it results in the death of the bacteria
| Trade Name | Tisomycin |
| Availability | Prescription only |
| Generic | Cycloserine |
| Cycloserine Other Names | alpha-Cycloserine, Cicloserina, cyclo-D-Serine, Cycloserine, Cyclosérine, Cycloserinum, D-Cycloserine, Orientomycin |
| Related Drugs | prednisone, ciprofloxacin, levofloxacin, Levaquin, rifampin, Deltasone, Sterapred, Prednicot |
| Type | |
| Formula | C3H6N2O2 |
| Weight | Average: 102.0919 Monoisotopic: 102.042927446 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tisomycin is a broad-spectrum antibiotic used in the treatment of tuberculosis and certain urinary tract infections (UTI).
Used in combination with up to 5 other drugs as a treatment for Mycobacterium avium complex (MAC) and is also used to treat tuberculosis (TB).
Tisomycin is also used to associated treatment for these conditions: Refractory Tuberculosis, Refractory Urinary Tract Infection
How Tisomycin works
Tisomycin is an analog of the amino acid D-alanine. It interferes with an early step in bacterial cell wall synthesis in the cytoplasm by competitive inhibition of two enzymes, L-alanine racemase, which forms D-alanine from L-alanine, and D-alanylalanine synthetase, which incorporates D-alanine into the pentapeptide necessary for peptidoglycan formation and bacterial cell wall synthesis.
Toxicity
Oral LD50 in mouse is 5290 mg/kg, and in rat is over 5000 mg/kg. Symptoms of a cycloserine overdose include drowsiness, confusion, headache, dizziness, irritability, numbness and tingling, difficulty speaking, paralysis, abnormal behavior, seizures, and unconsciousness.
Food Interaction
- Do not take with or immediately after a high-fat meal. High-fat meals may reduce the rate of absorption; however, the impact on the extent of absorption is unknown.
[Major] GENERALLY AVOID: Coadministration with alcohol may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone.
These effects may include dizziness, drowsiness, depression, anxiety, psychoses, memory impairment, confusion, and convulsions.
MANAGEMENT: Patients should be advised to avoid the consumption of alcohol during treatment with cycloserine or terizidone.
The use of these medications is contraindicated in patients with chronic alcohol consumption or alcoholism.
MONITOR CLOSELY: Coadministration with caffeine may potentiate some of the central nervous system adverse effects of cycloserine and its prodrug, terizidone.
These effects may include insomnia, excitability, irritability, anxiety, tremor, psychoses, and convulsions.
MANAGEMENT: Caution is advised when cycloserine or terizidone is used with caffeine.
Consumption of certain beverages or stimulants with very high caffeine levels should be avoided as a precautionary measure.
Tisomycin Drug Interaction
Unknown: amphetamine / dextroamphetamine, amphetamine / dextroamphetamine, ciprofloxacin, ciprofloxacin, sulfamethoxazole / trimethoprim, sulfamethoxazole / trimethoprim, risdiplam, risdiplam, ipratropium, ipratropium, tolvaptan, tolvaptan, levetiracetam, levetiracetam, tapentadol, tapentadol, pyridoxine, pyridoxine, ascorbic acid, ascorbic acid
Tisomycin Disease Interaction
Elimination Route
Rapidly and almost completely absorbed (70 to 90%) from the gastrointestinal tract following oral administration.
Half Life
Half-life in patients with normal renal function is 10 hours, and is prolonged in patients with impaired renal function.
Innovators Monograph
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