Tisscoat
Tisscoat Uses, Dosage, Side Effects, Food Interaction and all others data.
Sodium hyaluronate is a polysaccharide which functions as a tissue lubricant. It is widely used in ophthalmic surgery because it forms a viscoelastic solution in water which makes it a suitable substitute for aqueous and vitreous humour. Cartilage derivative; component of hyaline cartilage matrix that may repair cartilage & reduce synovial inflammation.
Sodium Chondroitin Sulfate: The effect of chondroitin sulfate in patients with osteoarthritis is likely the result of a number of reactions including its anti-inflammatory activity, the stimulation of the synthesis of proteoglycans and hyaluronic acid, and the decrease in catabolic activity of chondrocytes inhibiting the synthesis of proteolytic enzymes, nitric oxide, and other substances that contribute to damage cartilage matrix and cause death of articular chondrocytes. A recent review summarizes data from relevant reports describing the biochemical basis of the effect of chondroitin sulfate on osteoarthritis articular tissues. The rationale behind the use of chondroitin sulfate is based on the belief that osteoarthritis is associated with a local deficiency or degradation of natural substances, including internal chondroitin sulfate.
Recently, new mechanisms of action have been described for chondroitin sulfate. In an in vitro study, chondroitin sulfate reduced the IL-1β-induced nuclear factor-kB (NF-κB) translocation in chondrocytes. In addition, chondroitin sulfate has recently shown a positive effect on osteoarthritic structural changes occurred in the subchondral bone.
A review published in the Annals of Rheumatic Diseases describes all the documented evidence regarding the mechanisms of action of chondroitin sulfate
| Trade Name | Tisscoat |
| Generic | Sodium Chondroitin Sulfate + Sodium Hyaluronate |
| Weight | (40mg+30mg)/ml |
| Type | Viscoelastic Solution |
| Therapeutic Class | Ocular perioperative drugs |
| Manufacturer | Techno Drugs Ltd |
| Available Country | Bangladesh |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Cataract surgery, Cornea transplant surgery, Glaucoma surgery, Surgical aid in the anterior segment
Dosage
Tisscoat dosage
Depending on surgical procedure used. Recommended for single use. Injection into the chamber prior to or following delivery of the crystalline lens.
Side Effects
Transient rise in IOP
Precaution
Precautions are limited to those normally associated with the surgical procedure being performed. Although sodium hyaluronate and sodium chondroitin sulfate are highly purified biological polymers, the physician should be aware of the potential allergic risks inherent in the use of any biological material.
Interaction
Sodium hyaluronate: The safety and effectiveness of the use of sodium hyaluronate concomitantly with other intra-articular injection has not yet been established. As sodium hyaluronate is precipitated by quaternary amine bactericides or disinfectants eg, benzalkonium chloride and chlorhexidine, etc, adequate attention should be given.
Sodium Chondroitin Sulfate: Low potential for interactions. Cumarinic anticoagulants eg warfarin, platelet antiaggregant; tetracyclines
Pregnancy & Breastfeeding use
No data had found
Contraindication
Hypersensitivity
Acute Overdose
No case of over dosage has been reported to date.
Storage Condition
Hyronate injection should be stored in a cool (below 25° C) and dry place and protected from light. Protect from freezing.
Innovators Monograph
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