Tokovin
Tokovin Uses, Dosage, Side Effects, Food Interaction and all others data.
Tokovin Capsule is a Tokovin preparation. Tokovin acts as an antioxidant in the body. Tokovin protects polyunsaturated fatty acids (which are components of cellular membrane) and other oxygen-sensitive substances such as vitamin A & vitamin C from oxidation. Tokovin reacts with free radicals, which is the cause of oxidative damage to cell membranes, without the formation of another free radical in the process. The main pharmacological action of vitamin E in humans is its antioxidant effect.
In premature neonates irritability, edema, thrombosis and hemolytic anemia may be caused due to vitamin E deficiency. Creatinuria, ceroid deposition, muscle weakness, decreased erythrocyte survival or increased in vitro hemolysis by oxidizing agents have been identified in adults and children with low serum tocopherol concentrations.
Tokovin is a collective term used to describe 8 separate fat soluble antioxidants, most commonly alpha-tocopherol. Tokovin acts to protect cells against the effects of free radicals, which are potentially damaging by-products of the body's metabolism. Tokovin deficiency is seen in persons with abetalipoproteinemia, premature, very low birth weight infants (birth weights less than 1500 grams, or 3½ pounds), cystic fibrosis, and cholestasis and severe liver disease. Preliminary research suggests vitamin E may help prevent or delay coronary heart disease and protect against the damaging effects of free radicals, which may contribute to the development of chronic diseases such as cancer. It also protects other fat-soluble vitamins (A and B group vitamins) from destruction by oxygen. Low levels of vitamin E have been linked to increased incidence of breast and colon cancer.
| Trade Name | Tokovin |
| Generic | Vitamin E |
| Vitamin E Other Names | alpha-tocopherol |
| Weight | 100iu |
| Type | Caplet |
| Formula | C29H50O2 |
| Weight | Average: 430.7061 Monoisotopic: 430.381080844 |
| Protein binding | Vitamin E is bound to lipoproteins in blood. |
| Groups | Approved, Nutraceutical, Vet approved |
| Therapeutic Class | Vitamin-E Preparations |
| Manufacturer | Ifars Pharmaceuticals |
| Available Country | Indonesia |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
As a dietary supplement:
- Tokovin deficiency resulting from impaired absorption.
- Increased requirements due to diet rich in polyunsaturated fats.
- For healthy hair & skin
- As an Antioxidant
- Hemolytic anemia due to Tokovin deficiency
Therapeutic use
: Heavy metal poisoning, Hepatotoxin poisoning, Hemolytic anemia, Oxygen therapy and replacement therapy in nutritional deficiency states for the betterment of skin and hair.
Tokovin is also used to associated treatment for these conditions: Vitamin Deficiency, Long-chain omega-3 fatty acid supplementation, Dietary supplementation
How Tokovin works
The mechanism of action for most of vitamin E's effects are still unknown. Tokovin is an antioxidant, preventing free radical reactions with cell membranes. Though in some cases vitamin E has been shown to have pro-oxidant activity.
One mechanism of vitamin E's antioxidant effect is in the termination of lipid peroxidation. Tokovin reacts with unstable lipid radicals, producing stable lipids and a relatively stable vitamin E radical. The vitamin E radical is then reduced back to stable vitamin E by reaction with ascorbate or glutathione.
Dosage
Tokovin dosage
Betterment of Cardiovascular health: 400 mg - 800 mg / day
Deficiency syndrome in adults: 200 mg - 400 mg / day
Deficiency syndrome in children: 200 mg / day
Thalassemia: 800 mg / day
Sickle-cell anemia: 400 mg / day
Betterment of Skin & Hair: 200 mg - 400 mg / day (Topical use is also established for beautification)
Chronic cold in adults: 200 mg / day
Side Effects
Overdoses (>1g) have been associated with minor side effects, including hypertension, fatigue, diarrhea and myopathy
Toxicity
There is no data available for effects in pregnancy, breast feeding, hepatic impairment, or renal impairment. However, it appears that the process of vitamin E elimination is strict and self regulating enough that vitamin E toxicity is exceedingly rare. Studies showing adverse effects from excess vitamin E generally involve people consuming more than 1000mg/day for weeks to months.
Precaution
Tokovin may enhance the anticoagulant activity of anticoagulant drugs. Caution is advised in premature infants with high dose Tokovin supplementation, because of reported risk of necrotizing enterocilitis.
Interaction
Tokovin may impair the absorption of Vitamin A. Vitamin K functions impairement happens at the level of prothrombin formation and potentiates the effect of Warfarin.
Food Interaction
- Take with or without food. High-fat foods may increase absorption of Tokovin.
Volume of Distribution
0.41L/kg in premature neonates given a 20mg/kg intramuscular injection.
Elimination Route
10-33% of deuterium labelled vitamin E is absorbed in the small intestine. Absorption of Tokovin is dependant upon absorption of the fat in which it is dissolved. For patients with poor fat absorption, a water soluble form of vitamin E may need to be substituted such as tocopheryl polyethylene glycol-1000 succinate.
In other studies the oral bioavailability of alpha-tocopherol was 36%, gamma-tocotrienol was 9%. The time to maximum concentration was 9.7 hours for alpha-tocopherol and 2.4 hours for gamma-tocotrienol.
Half Life
44 hours in premature neonates given a 20mg/kg intramuscular injection. 12 minutes in intravenous injection of intestinal lymph.
Clearance
6.5mL/hr/kg in premature neonates given a 20mg/kg intramuscular injection.
Elimination Route
Alpha tocopherol is excreted in urine as well as bile in the feces mainly as a carboxyethyl-hydrochroman (CEHC) metabolite, but it can be excreted in it's natural form .
Pregnancy & Breastfeeding use
Use in pregnancy: Tokovin may be used in pregnancy in the normally recommended dose but the safety of high dose therapy has not been established.
Use in lactation: There appears to be no contraindication to breast feeding by mothers taking the normally recommended dose.
Contraindication
No known contraindications found.
Special Warning
Use in Children: Tokovin is safe for children
Acute Overdose
Large doses of vitamin E (more than 1 gm/day) have been reported to increase bleeding tendency in vitamin K deficient patients such as those taking oral anticoagulants.
Storage Condition
Store at a cool and dry place, Protect from light and moisture.
Innovators Monograph
You find simplified version here Tokovin
FAQ
What does Tokovin do for the body?
Tokovin acts as an antioxidant, helping to protect cells from the damage caused by free radicals. Free radicals are compounds formed when our bodies convert the food we eat into energy.
Can I take Tokovin everyday?
Tokovin is likely safe for most people when taken in doses lower than 1000 mg daily.
Does Tokovin help hair growth?
Tokovin may help support a healthy scalp and hair as it has natural antioxidant effects that could assist with maintaining hair growth.
What does Tokovin do for a woman?
Tokovin is key for strong immunity and healthy skin and eyes.Tokovin supplements have become popular as antioxidants. These are substances that protect cells from damage. However, the risks and benefits of taking Tokovin supplements are still unclear.
Does Tokovin stop hair loss?
Tokovin with its antioxidant properties, fights this oxidative stress, which is one of the major causes of severe hair fall. In a way, Tokovin blocks the erosion of your scalp tissues due to free radicals, thus, preventing hair fall as well as premature greying.
What are the side effects of Tokovin?
Tokovin side effects
- headache, dizziness, vision changes;
- a light-headed feeling, like you might pass out;
- unusual weakness or tired feeling;
- diarrhea, stomach cramps; or.
- easy bruising or bleeding (nosebleeds, bleeding gums).
Is Tokovin good for wrinkles?
Tokovin is a very potent antioxidant that can be used to fight wrinkles around the mouth.
Does Tokovin lighten the skin?
Some people use Tokovin with lemon juice or other ingredients to bleach the skin. There is no evidence that this works, and these products can cause side effects that include: damage to the skin.
How much Tokovin is safe in pregnancy?
Tokovin not recommended for pregnant women to improve maternal and perinatal outcomes.If need the recommended dose of Tokovin in human pregnancy is 22-30 mg/day.
Is Tokovin safe during breastfeeding?
Brand taken by the mother can concentrate in human milk, and thus excessive amounts may be harmful to a breastfeeding baby.
Can Tokovin cause birth defects?
Recent studies have shown that taking in too much Tokovin during pregnancy can cause birth defects in children. Specifically, too much Tokovin has been shown to cause heart defects in children after birth.
What happens if I take Tokovin everyday?
If you take Tokovin everyday may side effects increases with higher doses. Side effects can include nausea, fatigue, headache, and bleeding.
What is the best time to take Tokovin?
Best time to take Tokovin with your evening meal. Fat-soluble vitamins are dissolved in our bodies using fats. They are then carried into our bloodstream and perform essential functions.
When should I take Tokovin morning or night?
The best time to consume Tokovin supplements is with a meal at night. Eating a meal will allow for the best absorption rate of the vitamin into your body.
What is the benefits of taking Tokovin?
Tokovin supplements may prevent coronary heart disease, support immune function, prevent inflammation, promote eye health, and lower the risk of cancer.the research on these benefits is varied, and Tokovin supplementation is not right for everyone.
Can I take alcohol with Tokovin ?
Tokovin can mitigate the toxic effects of alcohol and can be suitably used as a potential therapeutic agent for alcohol-induced oxidative damage in liver.
Which food is rich in Tokovin?
Tokovin is found in the following foods:
- Vegetable oils (such as wheat germ, sunflower, safflower, corn, and soybean oils)
- Nuts (such as almonds, peanuts, and hazelnuts/filberts)
- Seeds (such as sunflower seeds)
- Green leafy vegetables (such as spinach and broccoli)
Does Tokovin make skin fair?
Tokovin in combination with and lemon juice, it helps whiten the skin. Lemon juice is a skin lightening agent, which is why it works best when combined with and used along with Tokovin.
Should I wash my face after applying Tokovin?
Wash your face and gently pat dry. If you have dry skin, you can leave the oil on overnight. If you're prone to breakouts or have sensitive skin, wash it off after 15 minutes.
Can I use Tokovin capsule with aloe vera gel?
You can use aloe vera and vitamin e capsules for skin whitening. When mixed with fresh aloe vera gel, Tokovin can brighten your dull and tired skin. You have to take some fresh aloe vera pulp and drops of oil from a Tokovin capsule. Blend these and apply it to your face as a mask.
How do I apply Tokovin oil to my hair?
Apply Tokovin oil to your hair:
- Massage it onto your scalp.
- Gently comb through with a wide-tooth comb.
- Let the oil sit for at least 15 minutes.
- When you're done, wash the oil out of your hair with your regular shampoo.
- If your hair already feels well moisturized, you can skip conditioner.
How often should I use Tokovin oil on your hair?
Tokovin usued at least three times a week for five to 10 minutes, and wash it off in an hour.
