Tonotan

Tonotan is a drug used as a vasodilator in humans and equines. Tonotan is a β₂ adrenoreceptor agonist that causes direct relaxation of uterine and vascular smooth muscle via β₂ receptors. Tonotan relaxes the uterine smooth muscles and is used for treatment of pre-term labor and dysmenorrhea. It is absorbed in the gastrointestinal system and is excreted in urine.

Researchers in this study reported that Tonotan was safe for treating acute pre-term labor and also as a maintenance therapy. Also, it was shown that prophylactic oral Tonotan does not lower the risk of pre-term labor in high-risk, single pregnancies.

This Tonotan works by relaxing the smooth muscle that surrounds small blood vessels causing vasodilation and potentially increasing blood flow to the hooves.

Common side effects of Tonotan are include:

• weakness.
• dizziness.
• flushing (feeling of warmth)
• upset stomach.
• vomiting.
• stomach pain.

This means that it is not known whether Tonotan will be harmful to an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant or could become pregnant during treatment.

Do not take this Tonotan without first talking to your doctor if you are pregnant or could become pregnant during treatment. It is not known whether Tonotan passes into breast milk. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

Tonotan can cause drowsiness, dizziness or faintness. Drinking alcohol with Tonotan can make you faint or feel even more drowsy or dizzy.

Use caution when driving, operating machinery, or performing other hazardous activities. Tonotan may cause dizziness. If you experience dizziness, avoid these activities.

Tonotan is used to relieve the symptoms of central and peripheral vascular diseases such as arteriosclerosis, Buerger's disease, and Raynaud's disease.

Tonotan is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor.

Tonotan comes in the form of tablet to take orally. It is usually taken 3-4 times in a day. It can be taken with food or on an empty stomach. Read the prescription label carefully before starting the medication.

This revealed a significant increase in distal limb temperature which occurred from 90 to 480 mins after Tonotan administration.

Tonotan to have a plasma half-life of <3. h with a large apparent volume of distribution.

Older adults should not usually take Tonotan because it is not as safe and effective as other medications that can be used to treat the same condition. if you are having surgery, including dental surgery, tell your doctor or dentist that you are taking Tonotan.

Tonotan should not be stopped abruptly without consulting the doctor as it may lead to unpleasant side-effects. Also, it is not suitable for some people. Inform your doctor before starting Tonotan if you have any bleeding disorder or heart problem. Do not do strenuous activities to avoid premature labour.

Take the missed dose as soon as you remember. However, if it is almost time for the next dose, skip the missed dose and take only the next regularly scheduled dose. Do not take a double dose of Tonotan.

Seek emergency medical attention if an overdose is suspected. Symptoms of an isoxsuprine overdose include weakness, lightheadedness, fainting, nausea, and vomiting.

Tonotan caused slight maternal hypotension and a transient acidosis, both of which returned to baseline values within 60 minutes.

There are no reports of problems with Tonotan in breastfeeding babies.

The important adverse reactions of Tonotan are tachycardia and orthostatic hypotension, but they occur only at high dosages.