Tolazine

Tolazine Uses, Dosage, Side Effects, Food Interaction and all others data.

A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazine can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.

Tolazine is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).

Trade Name Tolazine
Availability Discontinued
Generic Tolazoline
Tolazoline Other Names 2-Benzylimidazoline, Benzazoline, Tolazolin, Tolazolina, Tolazoline, Tolazolinum
Type
Formula C10H12N2
Weight Average: 160.2157
Monoisotopic: 160.100048394
Groups Approved, Vet approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Tolazine
Tolazine

Uses

Tolazine is a vasodilator used to treat pulmonary artery anomalies.

For the treatment of pulmonary artery anomalies

How Tolazine works

Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazine usually reduces pulmonary arterial pressure and vascular resistance.

Innovators Monograph

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