Tolazoline
Tolazoline Uses, Dosage, Side Effects, Food Interaction and all others data.
A vasodilator that apparently has direct actions on blood vessels and also increases cardiac output. Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the mechanisms of its therapeutic effects are not clear. It is used in treatment of persistent pulmonary hypertension of the newborn.
Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN).
| Trade Name | Tolazoline |
| Availability | Discontinued |
| Generic | Tolazoline |
| Tolazoline Other Names | 2-Benzylimidazoline, Benzazoline, Tolazolin, Tolazolina, Tolazoline, Tolazolinum |
| Type | |
| Formula | C10H12N2 |
| Weight | Average: 160.2157 Monoisotopic: 160.100048394 |
| Groups | Approved, Vet approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tolazoline is a vasodilator used to treat pulmonary artery anomalies.
For the treatment of pulmonary artery anomalies
How Tolazoline works
Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance.
Tolazoline Drug Interaction
Unknown: aspirin, barium sulfate, dexamethasone, dextran, low molecular weight, dextran, high molecular weight, epoetin alfa, ginkgo, glipizide, glycerin, guanidine, sodium iodide, arginine, morphine, acetaminophen, procaine penicillin, saccharomyces boulardii lyo, methyl salicylate topical, valproic acid, multivitamin, multivitamin
Tolazoline Disease Interaction
Major: vascular dysfunctionModerate: acid-base balance, histamine release, renal dysfunction
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