Tomudex
Tomudex Uses, Dosage, Side Effects, Food Interaction and all others data.
Tomudex (brand name Tomudex®) is a chemotherapy drug manufactured AstraZeneca Company, is an antimetabolite used in chemotherapy. It is an inhibitor of thymidylate synthase.
Tomudex belongs to a group of medicines known as antimetabolites. It is used to treat cancer of the colon and rectum. It may also be used to treat other kinds of cancer, as determined by your doctor. Tomudex blocks an enzyme needed by the cell to live. This interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by raltitrexed, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.
Trade Name | Tomudex |
Generic | Raltitrexed |
Raltitrexed Other Names | Raltitrexed |
Type | infusion |
Formula | C21H22N4O6S |
Weight | Average: 458.488 Monoisotopic: 458.126005146 |
Protein binding | >93% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | Hospira UK Ltd |
Available Country | Canada, United Kingdom, United States, Portugal, |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
Tomudex is a folate analog thymidylate synthase inhibitor used in the treatment of advanced colorectal cancer.
For the treatment of malignant neoplasm of colon and rectum
Tomudex is also used to associated treatment for these conditions: Advanced Colorectal Cancer, Pleural Mesotheliomas
How Tomudex works
Tomudex is an antineoplastic Agents and folic acid antagonists. Tomudex inhibits thymidylate synthase (TS) leading to DNA fragmentation and cell death. It is transported into cells via a reduced folate carrier. Inside the cell Tomudex is extensively polyglutamated, which enhances thymidylate synthase inhibitory power and duration. Inhibition of this enzyme results in decreased synthesis of thymidine triphosphate which is required for DNA synthesis.
Toxicity
Side effects include pale skin, troubled breathing, unusual bleeding or bruising, unusual tiredness or weakness, black, tarry stools, chest pain, chills, cough, fever, painful or difficult urination, shortness of breath, sore throat, sores, ulcers, or white spots on lips or in mouth, swollen glands, increase in bowel movements, loose stools, soft stools.
Food Interaction
No interactions found.Half Life
198 hours
Innovators Monograph
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