Tral
Tral Uses, Dosage, Side Effects, Food Interaction and all others data.
Tral is a muscarinic acetylcholine receptor antagonist which was presumably used in the treatment of gastric ulcer or diarrhea. It was once available under the tradename Tral marketed by Abbvie Inc. but has been discontinued. Proton pump inhibitors like Omeprazole and opiate anti-diarrheal agents like Loperamide have largely replaced the use of anti-muscarinics in the treatment of gastric ulcers and diarrhea due to their more favorable side effect profiles.
Tral reduces gastrointesitinal motility and gastric acid secretion .
| Trade Name | Tral |
| Generic | Hexocyclium |
| Type | |
| Formula | C20H33N2O |
| Weight | Average: 317.496 Monoisotopic: 317.258740111 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
The World Health Organization classifies hexocyclium as a drug for functional gastrointestinal disorders . Like other anti-muscarinic agents, hexocyclium was likely used to treat peptic ulcers or diarrhea.
How Tral works
Tral binds to and inhibits muscarinic acetylcholine receptors . This decreases gastric acid secretion by preventing the activation of M3 receptors on pareital cells and subsequent stimulation of gastric acid secretion . The antagonism of M3 receptors in the intestine inhibits smooth muscle contraction resulting in a decrease in motility. The binding of hexocyclium to other muscarinic receptor types produces typical anti-muscarinic side effects.
Innovators Monograph
You find simplified version here Tral
