Foznol

Foznol Uses, Dosage, Side Effects, Food Interaction and all others data.

Foznol is a phosphate binder commonly used in clinical practice. It is marketed under the trade name Fosrenol by Shire Pharmaceuticals. It is the largest of all pills filled in community pharmacies. Sometimes patients forget that Fosrenol is not swallowed whole, but instead should be chewed. This has led to severe choking. It is prescribed for treating high phosphate levels, mainly found in patients with chronic kidney disease. Lanthanum should be taken with meals and binds to phosphate in the diet, preventing phosphate absorption in the intestine.

In vitro studies have shown that lanthanum binds phosphate in the physiologically relevant pH range of 3 to 7. In simulated gastric fluid, lanthanum binds approximately 97% of the available phosphate at pH 3-5 and 67% at pH 7, when lanthanum is present in a two-fold molar excess to phosphate. Bile acids have not been shown to affect the phosphate binding affinity of lanthanum. In order to bind dietary phosphate, lanthanum carbonate must be administered with or immediately after meals.

Trade Name Foznol
Generic Lanthanum carbonate
Lanthanum carbonate Other Names Lanthanum (III) carbonate, Lanthanum sesquicarbonate, Lanthanum(3+) carbonate
Type
Formula C3La2O9
Weight Average: 457.835
Monoisotopic: 457.76695
Protein binding

In vitro, lanthanum is highly bound (>99%) to human plasma proteins, including human serum albumin, α1-acid glycoprotein, and transferrin.

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Foznol
Foznol

Uses

Foznol is a phosphate binder indicated for the reduction of serum phosphate in patients with end stage renal disease.

Used to reduce serum phosphate in patients with end stage renal disease (ESRD).

Foznol is also used to associated treatment for these conditions: Hyperphosphataemia

How Foznol works

Foznol is a phosphate binder that reduces absorption of phosphate by forming insoluble lanthanum phosphate complexes that pass through the gastrointestinal (GI) tract unabsorbed. Both serum phosphate and calcium phosphate product are reduced as a consequence of the reduced dietary phosphate absorption.

Toxicity

The symptoms associated with overdose are adverse reactions such as headache, nausea and vomiting. Foznol was not acutely toxic in animals by the oral route. No deaths and no adverse effects occurred in mice, rats or dogs after single oral doses of 2000 mg/kg.

Food Interaction

  • Take with food.

Elimination Route

Bioavailability very low (<0.002%) following single or multiple dose oral administration.

Half Life

Elimination half-life of 53 hours.

Clearance

In healthy volunteers administered intravenous lanthanum as the soluble chloride salt (120 μg), renal clearance was less than 2% of total plasma clearance.

Elimination Route

No information is available regarding the mass balance of lanthanum in humans after oral administration. In rats and dogs, the mean recovery of lanthanum after an oral dose was about 99% and 94%, respectively, and was essentially all from feces. Biliary excretion is the predominant route of elimination for circulating lanthanum in rats.

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*** Taking medicines without doctor's advice can cause long-term problems.
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