tricalcium citrate
tricalcium citrate Uses, Dosage, Side Effects, Food Interaction and all others data.
tricalcium citrate is a salt typically used as a source of calcium in a variety of over the counter supplements.
Increases plasma calcium levels leading to a decrease in calcium flux and increase in calcium deposition into bone
| Trade Name | tricalcium citrate |
| Generic | Calcium citrate |
| Calcium citrate Other Names | tricalcium citrate |
| Type | |
| Formula | C12H10Ca3O14 |
| Weight | Average: 498.432 Monoisotopic: 497.8948277 |
| Protein binding | About 46.4% of calcium is bound to plasma proteins . |
| Groups | Approved, Investigational |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
tricalcium citrate is an ingredient found in a variety of supplements and vitamins.
For use as an over the counter calcium supplement.
tricalcium citrate is also used to associated treatment for these conditions: Calcium Deficiency, Deficiency of Vitamin D3, Deficiency, Vitamin D, Folate deficiency, Hypocalcemia, Iron Deficiency (ID), Osteoporosis
How tricalcium citrate works
tricalcium citrate increases plasma calcium levels. This reduces calcium flux from osteocyte activity by reducing the secretion of parathyroid hormone (PTH) . Calcium does this by stimulating a G-protein coupled calcium receptor on the surface of parathyroid cells. The reduction in calcium flux increases the amount of calcium deposited in bone resulting in an increase in bone mineral density. The reduction in PTH secretion also reduces the amount of vitamin D metabolized to its active form, calcidiol. Since calcidiol increases the expression of calcium dependent ATPases and transient receptor potential cation channel subfamily V member 6 (TRPV6) both of which are involved in calcium uptake from the gut, a reduction in calcidiol results in less calcium absorption. Additionally, TRPV5, the channel responsible for calcium reabsorption in the kidney, is downregulated when PTH secretion is reduced thus increasing calcium excretion via the kidneys. Another hormone, calitonin, is likely involved in the reduction of bone resorption during periods of high plasma calcium.
Toxicity
Patients taking more than 4g of calcium a day are at risk of hypercalcemia and metabolic alkalosis . Chronic intake of calcium supplements is associated with adverse gastrointestinal symptoms such as constipation and flatulence .
Food Interaction
- Take with or without food.
Elimination Route
The percentage of calcium absorbed varies inversely with intake . Tmax of about 3.5-5h varying with formulation .
Elimination Route
Cleared via the kidneys but largely reabsorbed (98-99%) under normal conditions .
Innovators Monograph
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