63-Desulfohirudin (recombinant)

63-Desulfohirudin (recombinant) Uses, Dosage, Side Effects, Food Interaction and all others data.

63-Desulfohirudin (recombinant) is a direct inhibitor of human thrombin. It has a protein structure that is similar to that of hirudin, the naturally occurring anticoagulant present in the peripharyngeal glands in the medicinal leech, Hirudo medicinalis. Hirudin is a single polypeptide chain of 65 amino acids residues and contains three disulfide bridges. 63-Desulfohirudin (recombinant) has a chemical formula of C287H440N80O110S6 with a molecular weight of 6963.52.

It is mainly indicated for the prevention of deep vein thrombosis in hip replacement surgery patients.Common side effects include: Bleeding gums, collection of blood under the skin, coughing up blood, deep, dark purple bruise and difficulty with breathing or swallowing.

63-Desulfohirudin (recombinant) results in dose-dependent prolongation of the activated partial thromboplastin time (aPTT).

63-Desulfohirudin (recombinant)
Uses
Dosage
Side Effect
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Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
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Interaction With other Medicine
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Trade Name	63-Desulfohirudin (recombinant)
Availability	Discontinued
Generic	Desirudin
Desirudin Other Names	63-Desulfohirudin, 63-Desulfohirudin (Hirudo Medicinalis Isoform HV1), 63-Desulfohirudin (recombinant), Desirudin, Desirudin recombinant, Desirudina, Hirudin desirudin
Related Drugs	Xarelto, Eliquis, enoxaparin, apixaban, rivaroxaban, heparin
Type
Formula	C₂₈₇H₄₄₀N₈₀O₁₁₀S₆
Protein binding	Desirudin binds specifically and directly to thrombin, forming an extremely tight, non-covalent complex with an inhibitionconstant of approximately 2.6 x 10-13 M. Thus, free or protein bound desirudin immediately binds circulating thrombin.
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Indicated as prophylaxis of deep vein thrombosis for patients undergoing hip replacement surgery.

63-Desulfohirudin (recombinant) is also used to associated treatment for these conditions: Deep Vein Thrombosis

How 63-Desulfohirudin (recombinant) works

63-Desulfohirudin (recombinant) is a direct, highly selective thrombin inhibitor. Reversibly binds to the active thrombin site of free and clot-associated thrombin. Inhibits fibrin formation, activation of coagulation factors V, VII, and XIII, and thrombin-induced platelet aggregation resulting in a dose-dependent prolongation of the activated partial thromboplastin time (aPTT).

Toxicity

No data available.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.