Trimethadione

Trimethadione Uses, Dosage, Side Effects, Food Interaction and all others data.

An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)

Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.

Trimethadione
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Trimethadione
Availability	Discontinued
Generic	Trimethadione
Trimethadione Other Names	Trimetadiona, Trimethadion, Triméthadione, Trimethadione, Trimethadionum, Trimethinum, Troxidone
Related Drugs	diazepam, topiramate, levetiracetam, Keppra, Topamax, Valium
Type	Oral
Formula	C₆H₉NO₃
Weight	Average: 143.1406 Monoisotopic: 143.058243159
Protein binding	90%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country	United States
Last Updated:	September 19, 2023 at 7:00 am

Uses

Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.

Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.

Trimethadione is also used to associated treatment for these conditions: Refractory Petit mal Seizures

How Trimethadione works

Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.

Toxicity

Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.

Food Interaction

Avoid alcohol. The combination of alcohol with trimethadione may make you sleepy or dizzy.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.