Trimethadione

Trimethadione Uses, Dosage, Side Effects, Food Interaction and all others data.

An anticonvulsant effective in absence seizures, but generally reserved for refractory cases because of its toxicity. (From AMA Drug Evaluations Annual, 1994, p378)

Paramethadione and trimethadione are anticonvulsants indicated in the control of absence (petit mal) seizures that are refractory to treatment with other medications. Dione anticonvulsants are used in the treatment of epilepsy. They act on the central nervous system (CNS) to reduce the number of seizures.

Trade Name Trimethadione
Availability Discontinued
Generic Trimethadione
Trimethadione Other Names Trimetadiona, Trimethadion, Triméthadione, Trimethadione, Trimethadionum, Trimethinum, Troxidone
Related Drugs diazepam, topiramate, levetiracetam, Keppra, Topamax, Valium
Type Oral
Formula C6H9NO3
Weight Average: 143.1406
Monoisotopic: 143.058243159
Protein binding

90%

Groups Approved
Therapeutic Class
Manufacturer
Available Country United States
Last Updated: September 19, 2023 at 7:00 am
Trimethadione
Trimethadione

Uses

Trimethadione is an anticonvulsant agent indicated for the control of treatment-refractory petit mal seizures.

Used in the control of absence (petit mal) seizures that are refractory to treatment with other medications.

Trimethadione is also used to associated treatment for these conditions: Refractory Petit mal Seizures

How Trimethadione works

Dione anticonvulsants reduce T-type calcium currents in thalamic neurons, including thalamic relay neurons. It does so via the inhibition of voltage dependent T-type calcium channels. This raises the threshold for repetitive activity in the thalamus, and inhibits corticothalamic transmission. Thus, the abnormal thalamocortical rhythmicity, which is thought to underlie the 3-Hz spike-and-wave discharge seen on electroencephalogram(EEG) with absence seizures, is dampened.

Toxicity

Symptoms of overdose include clumsiness or unsteadiness, coma, dizziness (severe), drowsiness (severe), nausea (severe), and problems with vision.

Food Interaction

  • Avoid alcohol. The combination of alcohol with trimethadione may make you sleepy or dizzy.

[Moderate] GENERALLY AVOID: Alcohol may potentiate some of the pharmacologic effects of CNS-active agents.

Use in combination may result in additive central nervous system depression and
MANAGEMENT: Patients receiving CNS-active agents should be warned of this interaction and advised to avoid or limit consumption of alcohol.

Ambulatory patients should be counseled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.

Innovators Monograph

You find simplified version here Trimethadione

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http://classyfire.wishartlab.com/tax_nodes/C0000278
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http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0001831
http://www.hmdb.ca/metabolites/HMDB0014491
http://www.genome.jp/dbget-bin/www_bget?drug:D00392
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5576
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46504478
https://www.chemspider.com/Chemical-Structure.5374.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50227239
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=10827
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=9727
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL695
https://zinc.docking.org/substances/ZINC000001530710
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001265
http://www.pharmgkb.org/drug/PA164744924
https://www.drugs.com/mtm/trimethadione.html
https://en.wikipedia.org/wiki/Trimethadione
*** Taking medicines without doctor's advice can cause long-term problems.
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