Uramustine

Uramustine Uses, Dosage, Side Effects, Food Interaction and all others data.

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Table Of contents

• Uramustine
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Uramustine
Generic	Uracil mustard
Uracil mustard Other Names	5-aminouracil mustard, Aminouracil mustard, Uracil mustard, Uracil nitrogen mustard, Uramustina, Uramustine, Uramustinum
Type
Formula	C8H11Cl2N3O2
Weight	Average: 252.098 Monoisotopic: 251.022832025
Protein binding	5%
Groups	Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated:	September 19, 2023 at 7:00 am

Uses

Used for its antineoplastic properties.

How Uramustine works

After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

Innovators Monograph

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