Uramustine

Uramustine Uses, Dosage, Side Effects, Food Interaction and all others data.

Nitrogen mustard derivative of uracil. It is a alkylating antineoplastic agent that is used in lymphatic malignancies, and causes mainly gastrointestinal and bone marrow damage.

Uracil Mustard selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Uracil Mustard-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.

Trade Name Uramustine
Generic Uracil mustard
Uracil mustard Other Names 5-aminouracil mustard, Aminouracil mustard, Uracil mustard, Uracil nitrogen mustard, Uramustina, Uramustine, Uramustinum
Type
Formula C8H11Cl2N3O2
Weight Average: 252.098
Monoisotopic: 251.022832025
Protein binding

5%

Groups Approved
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Uramustine
Uramustine

Uses

Used for its antineoplastic properties.

How Uramustine works

After activation, it binds preferentially to the guanine and cytosine moieties of DNA, leading to cross-linking of DNA, thus inhibiting DNA synthesis and function.

Innovators Monograph

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*** Taking medicines without doctor's advice can cause long-term problems.
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