ventavis
ventavis Uses, Dosage, Side Effects, Food Interaction and all others data.
ventavis is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It is used to treat pulmonary arterial hypertension (PAH).
ventavis is a synthetic analogue of prostacyclin PGI2 that dilates systemic and pulmonary arterial vascular beds. It was shown to affect platelet aggregation, but whether this effect contributes to its vasodilatory action has not been elucidated. There are two diastereoisomers of iloprost and the 4S isomer is reported to exhibit a higher potency in dilating blood vessels compared to the 4R isomer.
Trade Name | ventavis |
Availability | Prescription only |
Generic | Iloprost |
Iloprost Other Names | Iloprost |
Related Drugs | sildenafil, tadalafil, Revatio, Adempas, Opsumit, ambrisentan |
Weight | 10µg/ml, , 10mcg/ml, 20mcg/ml |
Type | Nebuliser Solution, Solution, Inhalation Solution |
Formula | C22H32O4 |
Weight | Average: 360.494 Monoisotopic: 360.23005951 |
Protein binding | 60% |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | Bayer Ag, Bayer Plc |
Available Country | Saudi Arabia, United Kingdom, United States, France, Italy, Netherlands, Portugal, Spain, Switzerland, |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
ventavis is a synthetic prostacyclin analog indicated to treat pulmonary arterial hypertension (PAH).
Used for the treatment of pulmonary arterial hypertension.
ventavis is also used to associated treatment for these conditions: NYHA class III Pulmonary arterial hypertension, NYHA class IV Pulmonary arterial hypertension
How ventavis works
ventavis is a second generation structural analog of prostacyclin (PGI) with about ten-fold greater potency than the first generation stable analogs, such as carbaprostacyclin. ventavis binds with equal affinity to human prostacyclin (Prostanoid IP) and prostaglandin EP1 receptors. ventavis constricts the ilium and fundus circular smooth muscle as strongly as prostaglandin E2 (PGE2) itself. ventavis inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time. All of these properties help to antagonize the pathological changes that take place in the small pulmonary arteries of patients with pulmonary hypertension.
Toxicity
Overdoses can lead to hypotension, headache, flushing, nausea, vomiting, and diarrhea.
Food Interaction
- Avoid herbs and supplements with anticoagulant/antiplatelet activity. Taking iloprost with anticoagulant/antiplatelet herbs may increase the risk of bleeding occurring as an adverse effect. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.
ventavis Drug Interaction
Moderate: aspirin, aspirin, epinephrine, epinephrine, omega-3 polyunsaturated fatty acids, omega-3 polyunsaturated fatty acidsUnknown: charcoal, charcoal, amoxicillin / clavulanate, amoxicillin / clavulanate, Allergy , Allergy , ubiquinone, ubiquinone, glucose, glucose, sodium iodide, sodium iodide, acetaminophen, acetaminophen
ventavis Disease Interaction
Volume of Distribution
- 0.7 to 0.8 L/kg
Elimination Route
Rapidly absorbed with bioavailability of 63%
Half Life
20-30 minutes
Clearance
- 20 mL/min/kg [Normal subjects]
Innovators Monograph
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