Xigris (Drotrecogin Alfa)

Xigris (Drotrecogin Alfa) Uses, Dosage, Side Effects, Food Interaction and all others data.

Xigris (Drotrecogin Alfa) is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Xigris (Drotrecogin Alfa) was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.

Xigris (Drotrecogin Alfa) is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.Xigris (Drotrecogin Alfa) inhibits factor Va and VIIIa, thereby reducing the coagulability of blood.

Xigris (Drotrecogin Alfa)
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
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Interaction With other Medicine
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Trade Name	Xigris (Drotrecogin Alfa)
Generic	Drotrecogin alfa
Drotrecogin alfa Other Names	Activated protein C, Blood coagulation factor XIV (human), Drotrecogin alfa (activated), Drotrecogin alfa (activated), lyophilized, Drotrecogin alfa activated, Drotrecogin alfa, activated, Drotrecogin-alfa, Recombinant human activated protein C (rH-APC)
Type
Formula	C₁₇₈₆H₂₇₇₉N₅₀₉O₅₁₉S₂₉
Weight	55000.0 Da
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country	Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Iceland, Ireland, Italy, Latvia, Lebanon, Liechtenstein, Lithuania, Luxembourg, Malta, Netherlands, Norway, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden, United Kingdom, USA
Last Updated:	September 19, 2023 at 7:00 am

Uses

Xigris (Drotrecogin Alfa) is a form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.

For reduction of mortality in patients with severe sepsis.

How Xigris (Drotrecogin Alfa) works

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.