Drotrecogin Alfa Uses, Dosage, Side Effects and more

Drotrecogin Alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond. Drotrecogin Alfa was withdrawn from the market after a major study indicated that it was not effective in improving outcomes in patients with sepsis.

Drotrecogin Alfa is activated human protein C that is synthesized by recombinant DNA technology. It is a glycoprotein of approximately 55 kilodalton molecular weight, consisting of a heavy chain and a light chain linked by a disulfide bond.Drotrecogin Alfa inhibits factor Va and VIIIa, thereby reducing the coagulability of blood.

Trade Name	Drotrecogin Alfa
Generic	Drotrecogin alfa
Drotrecogin alfa Other Names	Activated protein C, Blood coagulation factor XIV (human), Drotrecogin alfa (activated), Drotrecogin alfa (activated), lyophilized, Drotrecogin alfa activated, Drotrecogin alfa, activated, Drotrecogin-alfa, Recombinant human activated protein C (rH-APC)
Type
Formula	C₁₇₈₆H₂₇₇₉N₅₀₉O₅₁₉S₂₉
Weight	55000.0 Da
Groups	Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated:	January 7, 2025 at 1:49 am

Uses

Drotrecogin Alfa is a form of recombinant activated human protein C used to reduce mortality in patients with severe sepsis by inhibiting coagulation Factors V and VIII.

For reduction of mortality in patients with severe sepsis.

How Drotrecogin Alfa works

Activated protein C combines with protein S on platelet surfaces and then degrades factor Va and factor VIIIa, thereby reducing blood coagulability.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.