Yesdol

Yesdol Uses, Dosage, Side Effects, Food Interaction and all others data.

Yesdol is an antiemetic agent used in the treatment of vomiting and vertigo. Yesdol overdose may result in serious toxicity in children.

Yesdol is used for control of nausea and vomiting. It has an antivertigo effect on the vestibular apparatus, inhibiting the chemoreceptor trigger zone to control nausea and vomiting, thus preventing motion sickness.

Trade Name Yesdol
Generic Diphenidol
Diphenidol Other Names Difenidol, Difénidol, Difenidolo, Difenidolum, Diphenidol
Type
Formula C21H27NO
Weight Average: 309.4452
Monoisotopic: 309.209264491
Groups Approved, Investigational, Withdrawn
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Yesdol
Yesdol

Uses

Yesdol is an antiemetic agent used for the prevention and symptomatic treatment of nausea and vomiting associated with various conditions as Meniere's disease and surgery of the middle and inner ear.

For use in the prevention and symptomatic treatment of peripheral (labyrinthine) vertigo and associated nausea and vomiting that occur in such conditions as Meniere's disease and surgery of the middle and inner ear. Also for the control of nausea and vomiting associated with postoperative states, malignant neoplasms, labyrinthine disturbances, antineoplastic agent therapy, radiation sickness, and infectious diseases.

Yesdol is also used to associated treatment for these conditions: Dizziness, Menière's Disease, Nausea, Postoperative, Prophylaxis against postoperative nausea and vomiting, Vomiting, Postoperative, Nausea, Postoperative

How Yesdol works

The mechanism by which diphenidol exerts its antiemetic and antivertigo effects is not precisely known. It is thought to diminish vestibular stimulation and depress labyrinthine function and as an antimuscarinic agent. An action on the medullary chemoreceptive trigger zone may also be involved in the antiemetic effect. Yesdol has no significant sedative, tranquilizing, or antihistaminic action. It has a weak peripheral anticholinergic effect.

Toxicity

Symptoms of overdose include drowsiness (severe); shortness of breath or troubled breathing; unusual tiredness or weakness (severe).

Food Interaction

No interactions found.

Elimination Route

Well absorbed from gastrointestinal tract following oral administration.

Half Life

4 hours

Innovators Monograph

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http://classyfire.wishartlab.com/tax_nodes/C0004150
http://classyfire.wishartlab.com/tax_nodes/C0003073
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI:4638
http://www.hmdb.ca/metabolites/HMDB0015361
http://www.genome.jp/dbget-bin/www_bget?drug:D03858
http://www.genome.jp/dbget-bin/www_bget?cpd:C06961
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=3055
https://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?sid=46506486
https://www.chemspider.com/Chemical-Structure.2947.html
http://www.bindingdb.org/bind/chemsearch/marvin/MolStructure.jsp?monomerid=50225701
https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=23370
https://www.ebi.ac.uk/chebi/searchId.do?chebiId=4638
https://www.ebi.ac.uk/chembldb/index.php/compound/inspect/CHEMBL936
https://zinc.docking.org/substances/ZINC000000968266
http://bidd.nus.edu.sg/group/cjttd/ZFTTDDRUG.asp?ID=DAP001133
http://www.pharmgkb.org/drug/PA164746037
https://www.drugs.com/cons/diphenidol.html
https://en.wikipedia.org/wiki/Diphenidol
*** Taking medicines without doctor's advice can cause long-term problems.
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