Zevalin Yttrium

Zevalin Yttrium Uses, Dosage, Side Effects, Food Interaction and all others data.

Indium or yttrium conjugated murine IgG1 kappa monoclonal antibody directed against the CD20 antigen, which is found on the surface of normal and malignant B lymphocytes. Ibritumomab is produced in Chinese hamster ovary cells and is composed of two murine gamma 1 heavy chains of 445 amino acids each and two kappa light chains of 213 amino acids each.

Ibritumomab is a murine monoclonal antibody against CD20 that has been radiolabeled with yttrium-90.

Zevalin Yttrium
Uses
Dosage
Side Effect
Precautions
Interactions
Uses during Pregnancy
Uses during Breastfeeding
Accute Overdose
Food Interaction
Half Life
Volume of Distribution
Clearance
Interaction With other Medicine
Contradiction
Storage

Trade Name	Zevalin Yttrium
Generic	Ibritumomab tiuxetan
Ibritumomab tiuxetan Other Names	Ibritumomab, Ibritumomab tiuxetan, mAb Murine (IGG1) Anti P19437 (CD20_MOUSE)
Type
Formula	C₆₃₈₂H₉₈₃₀N₁₆₇₂O₁₉₇₉S₅₄
Weight	143375.5 Da
Groups	Approved, Investigational
Therapeutic Class
Manufacturer
Available Country	Japan
Last Updated:	September 19, 2023 at 7:00 am

Uses

Zevalin Yttrium is a monoclonal anti-CD20 antibody used to treat B-cell non-Hodgkin's lymphoma via a conjugated radioactive isotope.

For treatment of non-Hodgkin's lymphoma

Zevalin Yttrium is also used to associated treatment for these conditions: Follicular Non-Hodgkin's Lymphoma, Follicular Non-Hodgkin's Lymphoma Refractory

How Zevalin Yttrium works

The Fab segment of the antibody targets the CD20 epitope on B-cells, allowing the radioactive yttrium to destroy the cell via production of beta particles.

Food Interaction

Avoid herbs and supplements with anticoagulant/antiplatelet activity. Individuals taking these herbs/supplements while taking ibritumomab tiuxetan should be monitored for thrombocytopenia more frequently. Examples include garlic, ginger, bilberry, danshen, piracetam, and ginkgo biloba.

Volume of Distribution

Binding observed on lymphoid cells of the bone marrow, lymph node, thymus, red and white pulp of the spleen, lymphoid follicles of the tonsil, and lymphoid nodules of other organs (e.g., large and small intestines)