Zhe Peng

Zhe Peng Uses, Dosage, Side Effects, Food Interaction and all others data.

Zhe Peng is a fluoroquinolone antibacterial which acts by inhibiting DNA synthesis in susceptible organisms via inhibition of both DNA gyrase (essential for bacterial reproduction) and topoisomerase IV (essential during bacterial cell division).

Zhe Peng is a synthetic broad-spectrum 8-methoxyfluoroquinolone antibacterial agent for oral or intravenous administration. is bactericidal and its mode of action depends on blocking of bacterial DNA replication by binding itself to an enzyme called DNA gyrase, which allows the untwisting required to replicate one DNA double helix into two. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian. Zhe Peng is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

Trade Name Zhe Peng
Availability Discontinued
Generic Gatifloxacin
Gatifloxacin Other Names Gatifloxacin, Gatifloxacine, Gatifloxacino, Gatifloxacinum
Related Drugs amoxicillin, prednisone, doxycycline, ciprofloxacin, cephalexin, metronidazole, azithromycin, clindamycin, ceftriaxone, levofloxacin
Type
Formula C19H22FN3O4
Weight Average: 375.3941
Monoisotopic: 375.159434412
Protein binding

20%

Groups Approved, Investigational
Therapeutic Class Antibacterial drugs
Manufacturer
Available Country China
Last Updated: September 19, 2023 at 7:00 am
Zhe Peng
Zhe Peng

Uses

Zhe Peng is used for the following infections:

  • Acute bacterial exacerbation of chronic bronchitis due to Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, or Staphylococcus aureus.
  • Acute sinusitis due to Streptococcus pneumoniae or Haemophilus influenzae.
  • Community-acquired pneumonia due to Streptococcus pneumoniae, Haemophilus influenzae, Haemophilus parainfluenzae, Moraxella catarrhalis, Staphylococcus aureus, Mycoplasma pneumoniae, Chlamydia pneumoniae, or Legionella pneumophila.
  • Uncomplicated skin and skin structure infections (i.e., simple abscesses, furuncles, folliculitis, wound infections, and cellulitis) due to Staphylococcus aureus or Streptococcus pyogenes.
  • Uncomplicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis.
  • Complicated urinary tract infections due to Escherichia coli, Klebsiella pneumoniae, or Proteus mirabilis.
  • Pyelonephritis due to Escherichia coli.
  • Uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae.
  • Acute, uncomplicated rectal infections in women due to Neisseria gonorrhoeae.

Zhe Peng is also used to associated treatment for these conditions: Bacterial Conjunctivitis, Ocular Infections, Irritations and Inflammations

How Zhe Peng works

The bactericidal action of Zhe Peng results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, and recombination.

Dosage

Zhe Peng dosage

Acute Bacterial Exacerbation of Chronic Bronchitis: 400 mg 5 days

Acute Sinusitis: 400 mg 10 days

Community-acquired Pneumonia: 400 mg 7-14 days

Uncomplicated Skin and Skin Structure Infections: 400 mg 7-10 days

Uncomplicated Urinary Tract Infections: 400 mg Single Dose or 200 mg 3 days

Complicated Urinary Tract Infections: 400 mg 7-10 days

Acute Pyelonephritis: 400 mg 7-10 days

Uncomplicated Urethral Gonnorrhea in Men: 400 mg Single dose

Zhe Peng can be administered without regard to food.

Side Effects

Zhe Peng is generally well tolerated. The most common side effects that can occur while taking this drug are usually mild and include nausea, vomiting, stomach pain, diarrhea, dizziness,and headache .

Precaution

Zhe Peng should be administered with caution in the presence of renal insufficiency.

Food Interaction

  • Drink plenty of fluids.
  • Take with or without food. The absorption is unaffected by food.

[Minor] Concurrent ingestion of calcium-fortified foods (i.e., cereal, orange juice) may alter the bioavailability of gatifloxacin.

The mechanism is chelation of calcium and the quinolone, resulting in decreased bioavailability.

In the case of orange juice, inhibition of intestinal transport mechanisms (P-glycoprotein or organic anion-transporting polypeptides) by flavones may also be involved.

Data have been conflicting: One study has reported no effect with milk coadministration.

Another study reported a modest decrease in gatifloxacin bioavailability (13.5% decrease in Cmax,12% decrease in AUC, 15% increase in total clearance) when taken with 12 ounces of calcium-fortified orange juice instead of water, which could be clinically significant if the infecting organisms have borderline susceptibilities.

The manufacturer states that gatifloxacin may be taken without regard to food, milk, or calcium.

Clinicians should be aware of the possibility of an interaction if subtherapeutic effects are observed.

Zhe Peng multivitamins interaction

[Moderate] ADJUST DOSING INTERVAL: Oral preparations that contain magnesium, aluminum, or calcium may significantly decrease the gastrointestinal absorption of quinolone antibiotics.

Absorption may also be reduced by sucralfate, which contains aluminum, as well as other polyvalent cations such as iron and zinc.

The mechanism is chelation of quinolones by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract.

The bioavailability of ciprofloxacin has been reported to decrease by as much as 90% when administered with antacids containing aluminum or magnesium hydroxide.

When coadministration cannot be avoided, quinolone antibiotics should be dosed either 2 to 4 hours before or 4 to 6 hours after polyvalent cation-containing products to minimize the potential for interaction.

When coadministered with Suprep Bowel Prep (magnesium

Please consult individual product labeling for specific recommendations.

Elimination Route

Well absorbed from the gastrointestinal tract after oral administration with absolute bioavailability of gatifloxacin is 96%

Half Life

7-14 hours

Pregnancy & Breastfeeding use

Pregnancy: Zhe Peng should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.

Lactation: It is not known whether Zhe Peng is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when gatifloxacin is administered to a nursing woman.

Contraindication

Zhe Peng is contraindicated in patients with a history of hypersensitivity of Zhe Peng, quinolone antimicrobial agents, or any other components of this product.

Special Warning

Renal Impaired patient:

  • Creatinine Clearance 40 mL/min: 400 mg every day.
  • Creatinine Clearance < 40 mL/min: 400 mg 200 mg every day.

Dialysis patients:

  • Hemodialysis: 400 mg 200 mg every day.
  • Continuous peritoneal dialysis: 400 mg 200 mg every day.

Pediatric use: The safety and effectiveness of Zhe Pengacin in pediatric populations (<18 years of age) have not been established.

Acute Overdose

Zhe Peng exhibits a low potential for acute toxicity in animal studies. In the event of acute oral overdose, the stomach should be emptied by inducing vomiting or by gastric lavage. The patient should be carefully observed (including ECG monitoring) and given symptomatic and supportive treatment. Adequate hydration should be maintained.

Innovators Monograph

You find simplified version here Zhe Peng

FAQ

What is Zhe Peng used for?

Zhe Peng eye drops are used to treat infections of the eye, such as bacterial conjunctivitis. Zhe Peng is an antibiotic of the fourth-generation fluoroquinolone family, that like other members of that family, inhibits the bacterial enzymes DNA gyrase and topoisomerase IV.

Is Zhe Peng eye drops safe?

Zhe Peng eye drops may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away: red, irritated, itchy, or teary eyes. blurred vision.

How does Zhe Peng work?

Zhe Peng works by killing bacteria that cause conjunctivitis.

What are the common side effects of Zhe Peng?

Common side effects of Zhe Peng are include:

  • mild eye irritation after using the medicine;
  • blurred vision;
  • eye redness;
  • red, puffy, or droopy eyelids;
  • dry or watery eyes;
  • feeling like something is in your eye;
  • headache; or.
  • skin itching or rash.

Is Zhe Peng safe during pregnancy?

Animal studies have revealed evidence of maternal toxicity, decreased fetal and placental weight, and delayed fetal skeletal ossification. There are no controlled data in human pregnancies.

Is Zhe Peng safe during breastfeeding?

Use of Zhe Peng is acceptable in nursing mothers with monitoring of the infant for possible effects on the gastrointestinal flora, such as diarrhea or candidiasi. However, it is preferable to use an alternate drug for which safety information is available.

Can I drive after taking Zhe Peng?

Zhe Peng can cause dizziness, blurring of your vision for a short time. Be cautious, and do not drive until you feel well.

When should be taken of Zhe Peng?

It is usually instilled every 2 hours while awake for 2 days, and then two to four times a day for 5 days. Instill Zhe Peng eye drops at around the same times every day.

Who should not take Zhe Peng?

Follow all directions on your medicine label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose of Zhe Peng?

An overdose of Zhe Peng ophthalmic is not expected to be dangerous. Seek emergency medical attention if anyone has accidentally swallowed the medication.

Can I take Zhe Peng for long term?

Use of this medication for prolonged or repeated periods may result in a new fungal eye infection. Do not use this medication for longer than prescribed.

Can I drink alcohol with Zhe Peng?

It's generally safe to drink alcohol in moderation while taking Zhe Peng.

How should I take Zhe Peng ?

Take Zhe Peng exactly as it was prescribed for you. Do not take it in larger doses or for longer than recommended by your doctor. Take each dose with a full glass (8 ounces) of water. Drink plenty of fluid while taking Zhe Peng. Take each dose at the same time every day. You may take Zhe Peng with or without food.

*** Taking medicines without doctor's advice can cause long-term problems.
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