Zhuo Qing
Zhuo Qing Uses, Dosage, Side Effects, Food Interaction and all others data.
Zhuo Qing binds to 30S subunit of the bacterial ribosome, thus inhibiting protein synthesis. It has modest activity against a wide range of gm+ve and gm-ve organisms, though anaerobic organisms are mostly resistant.
Zhuo Qing is an aminocyclitol antibiotic produced by a species of soil microorganism designated as Streptomyces spectabilis. In vitro studies have shown spectinomycin to be active against most strains of Neisseria gonorrhoeae (minimum inhibitory concentration <7.5 to 20 mcg/mL). Footprint studies indicate that spectinomycin exerts regional effects on ribosomal structure.
| Trade Name | Zhuo Qing |
| Availability | Discontinued |
| Generic | Spectinomycin |
| Spectinomycin Other Names | Actinospectacina, Espectinomicina, Spectinomicina, Spectinomycin, Spectinomycine, Spectinomycinum |
| Type | |
| Formula | C14H24N2O7 |
| Weight | Average: 332.3496 Monoisotopic: 332.158351132 |
| Protein binding | Not significant |
| Groups | Approved, Investigational, Vet approved |
| Therapeutic Class | Miscellaneous Antibiotics |
| Manufacturer | |
| Available Country | China |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
Zhuo Qing Sterile Powder is used for the treatment of:
- Acute gonorrheal urethritis and proctitis in the male
- Acute gonorrheal cervicitis and proctitis in the female
- Men and women with known recent exposure to gonorrhea should be treated as those known to have gonorrhea.
How Zhuo Qing works
Zhuo Qing is an inhibitor of protein synthesis in the bacterial cell; the site of action is the 30S ribosomal subunit. It is bactericidal in its action.
Dosage
Zhuo Qing dosage
Adults (Men and Women): Inject 5 ml intramuscularly for a 2 gm dose.This is also the recommended dose for patients being treated after failure of previous antibiotic therapy
Intramuscular injections should be made deep into the upper outer quadrant of the gluteal muscle.
Zhuo Qing Sterile 2 grams Powder: Reconstitute with 3.2 ml of the accompanying water for injection with 0.9% Benzyl alcohol. Shake vials vigorously immediately after adding diluent and before withdrawing dose.
Side Effects
The following reactions were observed during the single dose clinical trials: soreness at the injection site, urticaria, dizziness, nausea, chills, fever and insomnia
Toxicity
Acute oral toxicity (LD50): >5000 mg/kg [Rat]. Information on overdosage in humans is not available.
Precaution
The usual precautions should be observed with atopic individuals. Prescribing Zhuo Qing Sterile Powder in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria
Interaction
May result in lithium toxicity when used concurrently. May increase or prolong the neuromuscular blocking effect of atracurium.
Zhuo Qing Disease Interaction
Elimination Route
Rapidly and almost completely absorbed after intramuscular injection.
Half Life
1 to 3 hours in patients with normal renal function and 10 to 30 hours in patients with impaired renal function with a creatinine clearance < 20 mL per minute.
Pregnancy & Breastfeeding use
Pregnancy Category B. Since there are no controlled studies of Zhuo Qing in pregnant women, and because animal reproduction studies are not always predictive of human responses, Zhuo Qing should be used during pregnancy only if clearly needed.
Nursing Mothers It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Zhuo Qing is administered to a nursing woman.
Contraindication
The use of Zhuo Qing Sterile Powder is contraindicated in patients previously found hypersensitive to it.
Acute Overdose
Information on overdosage in humans is not available. Hemodialysis has been reported to aid in the removal of intravenously administered Zhuo Qing from the body.
Storage Condition
Store between 20-25°C. Reconstituted solution should be used within 24 hr after preparation.
Innovators Monograph
You find simplified version here Zhuo Qing
Zhuo Qing contains Spectinomycin see full prescribing information from innovator Zhuo Qing Monograph, Zhuo Qing MSDS, Zhuo Qing FDA label
FAQ
What is Zhuo Qing used for?
Zhuo Qing is an antibiotic. It fights bacteria in the body.
Zhuo Qing is used in the treatment of gonorrhea.
Zhuo Qing may also be used for purposes other than those listed here.
How should I take Zhuo Qing?
Zhuo Qing will be administered as an injection by a healthcare provider.
What are the common side effects of Zhuo Qing?
The common sde effects of Zhuo Qing are include:
- nausea;
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- dizziness;
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- soreness at the injection site; or
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- fever.
Is Zhuo Qing safe during breastfeeding?
Do not use Zhuo Qing without first talking to your doctor if you are pregnant or could become pregnant during treatment.
Is Zhuo Qing safe during pregnancy?
It is not known whether Zhuo Qing passes into breast milk. Do not take Zhuo Qing without first talking to your doctor if you are breast-feeding a baby.
How many days should I take Zhuo Qing?
A minimum of 10 days of therapy is recommended.
How do I give a Zhuo Qing injection?
Inject 5 mL intramuscularly for a 2-gram dose. This is also the recommended dose for patients being treated after failure of previous antibiotic therapy.
Can Zhuo Qing cure typhoid?
Effective Against Disease for Which No cure Was Known 3 doctors reports find of 5 Persons Treated During Experiments, 3 Were Cured by Philadelphia Physicians.
Can Zhuo Qing cure staphylococcus?
Zhuo Qing and Kanamycin were once effective against Staphylococcal infections. They have developed resistance by modifying enzymes, changing the ribosomal attachment sites and by actively pushing out the drug from the bacteria.
Is Zhuo Qing a plant?
Zhuo Qing formulations used in plant agriculture are produced using Streptomyces griseus subsp. griseus, which carries strA for self-resistance to the antibiotic.
Who should not take Zhuo Qing?
The risk is higher if you have kidney disease, if you are receiving high doses of this medication, if you use this drug for a long time, if you are an older adult (older than 60 years), or if you develop a severe loss of body water (become dehydrated).
Is Zhuo Qing an antifungal?
Zhuo Qing is an antibiotic antifungal drug, an antibiotic fungicide and a member of Zhuo Qing.
Is Zhuo Qing used for tuberculosis?
Zhuo Qing is an aminoglycoside antibiotic derived from Streptomyces griseus that is used in the treatment of tuberculosis and sensitive Gram-negative infections.
What bacteria does Zhuo Qing target?
Zhuo Qing is an antibiotic that inhibits both Gram-positive and Gram-negative bacteria, and is therefore a useful broad-spectrum antibiotic.
Is Zhuo Qing effective against E coli?
Zhuo Qing treatment enhances the growth of E. coli by nitrate respiration.
Why is Zhuo Qing so effective?
Zhuo Qing is an effective antibiotic because its structure is similar to that of the anticodons that would usually bind to the ribosome.
What happens if I miss a dose?
Since Zhuo Qing is usually administered as a single injection, missing dose is not likely to occur.
What happens if I overdose?
Seek emergency medical attention if an overdose of spectinomycin is suspected.
Symptoms of a spectinomycin overdose are not known.
