123I-FP-CIT
123I-FP-CIT Uses, Dosage, Side Effects, Food Interaction and all others data.
Ioflupane (I-123) is a radiopharmaceutical used to image dopamine neurons and diagnose Parkinsonian syndromes.
iodine-123 labeled ioflupanebinds selectively to striatal presynaptic dopamine neurons by binding reversibly to presynaptic dopamine transporters.
| Trade Name | 123I-FP-CIT |
| Generic | Ioflupane I-123 |
| Ioflupane I-123 Other Names | 123I-FP-CIT, 123I-Ioflupane, Iodine ioflupane (123I), Ioflupane (123I), Ioflupane I 123, Ioflupane I(123), Ioflupano (123I), Ioflupanum (123I) |
| Type | |
| Formula | C18H23FINO2 |
| Weight | Average: 427.291 Monoisotopic: 427.076880092 |
| Groups | Approved |
| Therapeutic Class | |
| Manufacturer | |
| Available Country | |
| Last Updated: | September 19, 2023 at 7:00 am |
Uses
123I-FP-CIT is a radiopharmaceutical used in single photon emission computed tomography (SPECT) brain imaging to help diagnose patients with suspected Parkinsonian syndromes.
123I-FP-CIT is a SPECT (single photon emission computerized tomography) agent used to distinguish between Parkinson’s syndrome tremors and essential tremor.
123I-FP-CIT is also used to associated treatment for these conditions: Parkinsonian Syndromes
How 123I-FP-CIT works
Iodine-123 labeled ioflupane binds to presynaptic dopamine transporters. When Iodine-123 decays, a gammay ray is emmitted and detected through SPECT.
Food Interaction
- Take with or without food.
Volume of Distribution
Compared to the entire brain, about 30% of radioactivity is taken up by the striatum.
Elimination Route
Absorption is 100% because administered I.V.
Half Life
Half life is 13.2 hours.
Elimination Route
About 60% is excreted in the urine and 14% in the feces after 48 hours.
Innovators Monograph
You find simplified version here 123I-FP-CIT
