17-Deacylnorgestimate
17-Deacylnorgestimate Uses, Dosage, Side Effects, Food Interaction and all others data.
17-Deacylnorgestimate is a drug used in contraception. 17-Deacylnorgestimate is the active progestin responsible for the progestational activity that occurs in women after application of ORTHO EVRA patch.
17-Deacylnorgestimate is used for contraception and menopausal hormonal therapy transdermally or in combination with ethinyl estradiol as a vaginal ring. 17-Deacylnorgestimate, in combination with ethinyl estradiol inhibits ovulation by suppressing gonadotropins.
Trade Name | 17-Deacylnorgestimate |
Generic | Norelgestromin |
Norelgestromin Other Names | 17-Deacetylnorgestimate, 17-Deacylnorgestimate, D-Norgestrel 3-oxime, Deacetylnorgestimate, Levonorgestrel 3-oxime, Levonorgestrel oxime, Norelgestromin, Norelgestromina, Norplant 3-oxime |
Type | |
Formula | C21H29NO2 |
Weight | Average: 327.468 Monoisotopic: 327.219829178 |
Groups | Approved, Investigational |
Therapeutic Class | |
Manufacturer | |
Available Country | |
Last Updated: | September 19, 2023 at 7:00 am |
Uses
17-Deacylnorgestimate is a progestin used for the prevention of pregnancy in women who elect to use a transdermal patch as a method of contraception.
17-Deacylnorgestimate is used for contraception and menopausal hormonal therapy. 17-Deacylnorgestimate may potentially be used in breast cancer treatment due to its inhibitory effect on estrone sulfatase . They convert sulfated steroid precursors to estrogen during pregnancy.
17-Deacylnorgestimate is also used to associated treatment for these conditions: Polycystic Ovarian Syndrome, Transdermal contraception therapy
How 17-Deacylnorgestimate works
17-Deacylnorgestimate inhibits estrone sulfatase, which converts sulfated steroid precursors to estrogen during pregnancy. Norgelgestromin/ethinylestradiol suppresses follicular development, induces changes to the endometrium, which decreases chances of implantation and thickens the cervical mucus, impeding sperm swimming into the uterus. It also has similar agonisting binding affinities as its parent compound, Norgestimate, for progesterone and estrogen receptors.
Food Interaction
No interactions found.Innovators Monograph
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