Acthrel

Acthrel Uses, Dosage, Side Effects, Food Interaction and all others data.

Corticotropin-releasing factor is studied in the treatment of brain cancer. It is made naturally by the hypothalamus (a part of the brain) and can also be made in the laboratory. Human corticotropin-releasing factor may help reduce symptoms caused by edema (swelling) of the brain. It is a type of neurohormone, also called hCRF.

Table Of contents

• Acthrel
• Uses
• Dosage
• Side Effect
• Precautions
• Interactions
• Uses during Pregnancy
• Uses during Breastfeeding
• Accute Overdose
• Food Interaction
• Half Life
• Volume of Distribution
• Clearance
• Interaction With other Medicine
• Contradiction
• Storage

Trade Name	Acthrel
Availability	Prescription only
Generic	Corticorelin
Corticorelin Other Names	Corticoliberin human, Corticorelin, Corticorelin (human), Corticotropin releasing hormone human, Corticotropin-releasing factor, Corticotropin-releasing hormone, hCRF, Human corticoliberin, Human corticotropin-releasing factor
Related Drugs	dexamethasone, Decadron, cyproheptadine, mifepristone
Weight	100mcg,
Type	Intravenous powder for injection
Groups	Investigational
Therapeutic Class
Manufacturer
Available Country	United States,
Last Updated:	September 19, 2023 at 7:00 am

Uses

Acthrel is a synthetic corticotropin-releasing factor analog used to diagnose causes of excessive adrenocorticotropic hormone (ACTH) production.

Investigated for use/treatment in brain cancer and neurologic disorders.

How Acthrel works

Corticotropin-releasing factor is produced by neuroendocrine cells in the paraventricular nucleus of the hypothalamus and is released from neurosecretory terminals of these neurons into the primary capillary plexus of the hypothalamo-hypophyseal portal system. The portal system carries the Corticotropin-releasing hormone(CRH) to the anterior lobe of the pituitary where it stimulates the secretion of corticotropin (ACTH) and other biologically active substances.

Acthrel Hypertension interaction

[Major] Adrenocorticotropic agents may cause hypernatremia, hypokalemia, fluid retention, and elevation in blood pressure.

Therapy with these agents, particularly if intended for longer than brief periods, should be administered cautiously in patients with preexisting fluid retention or conditions that may be aggravated by these effects.

Dietary sodium restriction and potassium supplementation may be advisable.

The manufacturers consider the use of adrenocorticotropic agents to be contraindicated in patients with congestive heart failure or uncontrolled hypertension.

Acthrel Disease Interaction

Major: (+) tuberculin test, adrenal insufficiency, electrolyte imbalance, fluid retention, GI perforation, hyperadrenocorticism, infections, ocular herpes simplex, osteoporosis, PUD, scleroderma, vaccinationModerate: cirrhosis, depression/psychoses, diabetes, elevated IOP, hypothyroidism, myasthenia gravis, myopathy, thromboembolism

Innovators Monograph

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