Ajmalin

Ajmalin Uses, Dosage, Side Effects, Food Interaction and all others data.

An alkaloid found in the root of Rauwolfia serpentina, among other plant sources. It is a class Ia antiarrhythmic agent that apparently acts by changing the shape and threshold of cardiac action potentials. Ajmalin produces potent sodium channel blocking effects and a very short half-life which makes it a very useful drug for acute intravenous treatments. The drug has been very popular in some countries for the treatment of atrial fibrillation in patients with the Wolff–Parkinson–White syndrome and in well tolerated monomorphic ventricular tachycardias. It has also been used for many years as a drug to challenge the conduction system of the heart in cases of bundle branch block and syncope. In these cases, abnormal prolongation of the HV interval has been taken as a proof for infrahisian conduction defects tributary for permanent pacemaker implantation.

Ajmalin is a class 1A antiarrhythmic agent. By interfering with the sodium channels, this drug allows for improvement in abnormal rhythms of the heart

Trade Name Ajmalin
Generic Ajmaline
Ajmaline Other Names Ajmalin, Ajmaline
Type
Formula C20H26N2O2
Weight Average: 326.4326
Monoisotopic: 326.199428086
Groups Approved, Experimental
Therapeutic Class
Manufacturer
Available Country
Last Updated: September 19, 2023 at 7:00 am
Ajmalin
Ajmalin

Uses

Ajmalin is an antiarrhythmic used to manage a variety of forms of tachycardias.

For use as an antiarrhythmic agent.

Ajmalin is also used to associated treatment for these conditions: Junctional ectopic tachycardia, Symptomatic Supraventricular Tachycardia, Ventricular Tachycardia (VT), Persistent Ventricula

How Ajmalin works

The class I antiarrhythmic agents interfere with the sodium channel. A class IA agent lengthens the action potential (right shift) which brings about improvement in abnormal heart rhythms. This drug in particular has a high affinity for the Nav 1.5 sodium channel.

Innovators Monograph

You find simplified version here Ajmalin

*** Taking medicines without doctor's advice can cause long-term problems.
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